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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F12%3A43902581%21RIV13-MSM-11120___
rdf:type
n6:Vysledek skos:Concept
dcterms:description
Since the placenta is being continuously remodeled during normal placental development, extracellular nucleic acids of both fetal and placental origin, packed into either trophoblast-derived apoptotic bodies or shedding syncytiotrophoblast microparticles, may be detected in maternal circulation during the course of normal gestation. Placental-insufficiency-related pregnancy complications have been shown to be associated with excessive placental trophoblast apoptosis and shedding of placenta debris. Recent advances in the field are reviewed with a focus on the diagnostic potential of particular molecular biomarkers and their eventual implementation in the currently used predictive and diagnostic algorithms for placental-insufficiency-related pregnancy complications Since the placenta is being continuously remodeled during normal placental development, extracellular nucleic acids of both fetal and placental origin, packed into either trophoblast-derived apoptotic bodies or shedding syncytiotrophoblast microparticles, may be detected in maternal circulation during the course of normal gestation. Placental-insufficiency-related pregnancy complications have been shown to be associated with excessive placental trophoblast apoptosis and shedding of placenta debris. Recent advances in the field are reviewed with a focus on the diagnostic potential of particular molecular biomarkers and their eventual implementation in the currently used predictive and diagnostic algorithms for placental-insufficiency-related pregnancy complications
dcterms:title
Extracellular Nucleic Acids in Maternal Circulation as Potential Biomarkers for Placental Insufficiency Extracellular Nucleic Acids in Maternal Circulation as Potential Biomarkers for Placental Insufficiency
skos:prefLabel
Extracellular Nucleic Acids in Maternal Circulation as Potential Biomarkers for Placental Insufficiency Extracellular Nucleic Acids in Maternal Circulation as Potential Biomarkers for Placental Insufficiency
skos:notation
RIV/00216208:11120/12:43902581!RIV13-MSM-11120___
n6:predkladatel
n16:orjk%3A11120
n4:aktivita
n14:I
n4:aktivity
I
n4:cisloPeriodika
7
n4:dodaniDat
n10:2013
n4:domaciTvurceVysledku
n19:2133997
n4:druhVysledku
n15:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n8:predkladatel
n4:idSjednocenehoVysledku
135944
n4:idVysledku
RIV/00216208:11120/12:43902581
n4:jazykVysledku
n11:eng
n4:klicovaSlova
hypertensive disorders; hypermethylated RASSF1A; messenger-rna concentrations; pregnancy-associated micrornas; noninvasive prenatal-diagnosis; intrauterine growth restriction; free fetal DNA
n4:klicoveSlovo
n9:messenger-rna%20concentrations n9:free%20fetal%20DNA n9:hypermethylated%20RASSF1A n9:hypertensive%20disorders n9:noninvasive%20prenatal-diagnosis n9:intrauterine%20growth%20restriction n9:pregnancy-associated%20micrornas
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[03DBFB79FA72]
n4:nazevZdroje
DNA and Cell Biology
n4:obor
n18:EB
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
1
n4:rokUplatneniVysledku
n10:2012
n4:svazekPeriodika
31
n4:tvurceVysledku
Hromadníková, Ilona
n4:wos
000306357200011
s:issn
1044-5498
s:numberOfPages
11
n13:doi
10.1089/dna.2011.1530
n12:organizacniJednotka
11120