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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F12%3A43898608%21RIV13-MSM-11120___
rdf:type
skos:Concept n14:Vysledek
dcterms:description
The aim of this study was to evaluate the incidence and epidemiological characteristics of infective endocarditis (IE) in the Czech Republic. These results represent the first data on the epidemiology of IE from the post-communist countries. This was a prospective multi-centre observational study monitoring the occurrence of IE in the catchment areas of 29 hospitals during a 12-month period. The total monitored territory involved a population of 3.9 million people (37.7% of the total Czech population). Patients were included in the study if they had a diagnosis of possible or define endocarditis according to the modified Duke criteria. One hundred and thirty-four episodes of IE in 132 patients were reported. Thus the crude incidence of IE was 3.4 cases/100,000 inhabitants/y. Vegetations were most frequetly found on the aortic and mitral valves. The most frequent agent was Straphylococcus aureus (29.9%). The aetiology remained unexplained in 33.6% of cases, mainly because of previous antibiotic therapy. Surgical intervention during antibiotic therapy was performed in 36 patients (27.5%). Thirty-six patients died during hospitalization (in-hospital mortality rate 27.5%). The most common predisposing cardiac factors were remote cardiac surgery (19.4%) and degenerative valvular changes (11.9%). The most commont extracardiac factors were pyogenic infections of skin and soft tissues (13.0%) and chronic haemodialysis (8.2%). Our results document the changing epidemiological characteristics of IE, namely an increasing incidence of the disease and an increasing role of Staphylococcus aureus as a major pathogen. A shift was evident in predisposing factors for IE: almost 39% of IE episodes were associated with both cardiac and extracardiac modern medical procedures. The aim of this study was to evaluate the incidence and epidemiological characteristics of infective endocarditis (IE) in the Czech Republic. These results represent the first data on the epidemiology of IE from the post-communist countries. This was a prospective multi-centre observational study monitoring the occurrence of IE in the catchment areas of 29 hospitals during a 12-month period. The total monitored territory involved a population of 3.9 million people (37.7% of the total Czech population). Patients were included in the study if they had a diagnosis of possible or define endocarditis according to the modified Duke criteria. One hundred and thirty-four episodes of IE in 132 patients were reported. Thus the crude incidence of IE was 3.4 cases/100,000 inhabitants/y. Vegetations were most frequetly found on the aortic and mitral valves. The most frequent agent was Straphylococcus aureus (29.9%). The aetiology remained unexplained in 33.6% of cases, mainly because of previous antibiotic therapy. Surgical intervention during antibiotic therapy was performed in 36 patients (27.5%). Thirty-six patients died during hospitalization (in-hospital mortality rate 27.5%). The most common predisposing cardiac factors were remote cardiac surgery (19.4%) and degenerative valvular changes (11.9%). The most commont extracardiac factors were pyogenic infections of skin and soft tissues (13.0%) and chronic haemodialysis (8.2%). Our results document the changing epidemiological characteristics of IE, namely an increasing incidence of the disease and an increasing role of Staphylococcus aureus as a major pathogen. A shift was evident in predisposing factors for IE: almost 39% of IE episodes were associated with both cardiac and extracardiac modern medical procedures.
dcterms:title
Incidence, predisposing factors, and aetiology of infective endocarditis in the Czech Republic Incidence, predisposing factors, and aetiology of infective endocarditis in the Czech Republic
skos:prefLabel
Incidence, predisposing factors, and aetiology of infective endocarditis in the Czech Republic Incidence, predisposing factors, and aetiology of infective endocarditis in the Czech Republic
skos:notation
RIV/00216208:11120/12:43898608!RIV13-MSM-11120___
n14:predkladatel
n19:orjk%3A11120
n6:aktivita
n11:I
n6:aktivity
I
n6:cisloPeriodika
4
n6:dodaniDat
n9:2013
n6:domaciTvurceVysledku
n8:2562839 n8:9590765 n8:3740188
n6:druhVysledku
n13:J
n6:duvernostUdaju
n7:S
n6:entitaPredkladatele
n15:predkladatel
n6:idSjednocenehoVysledku
141070
n6:idVysledku
RIV/00216208:11120/12:43898608
n6:jazykVysledku
n18:eng
n6:klicovaSlova
Czech Republic; predisposing factors; aetiology; incidence; Infective endocarditis
n6:klicoveSlovo
n12:predisposing%20factors n12:Czech%20Republic n12:incidence n12:aetiology n12:Infective%20endocarditis
n6:kodStatuVydavatele
NO - Norské království
n6:kontrolniKodProRIV
[7B1004E770F9]
n6:nazevZdroje
Scandinavian Journal of Infectious Diseases
n6:obor
n17:FN
n6:pocetDomacichTvurcuVysledku
3
n6:pocetTvurcuVysledku
5
n6:rokUplatneniVysledku
n9:2012
n6:svazekPeriodika
44
n6:tvurceVysledku
Beneš, Jiří Džupová, Olga Machala, Ladislav
n6:wos
000302077000002
s:issn
0036-5548
s:numberOfPages
6
n4:doi
10.3109/00365548.2011.632643
n16:organizacniJednotka
11120