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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F11%3A00003582%21RIV12-MSM-11120___
rdf:type
n12:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1186/bcr2946
dcterms:description
Protein tyrosine kinases (PTKs) are frequently overexpressed and/or activated in human malignancies, and regulate cancer cell proliferation, cellular survival, and migration. As such, they have become promising molecular targets for new therapies. The non-receptor PTK termed breast tumor kinase (Brk/PTK6) is overexpressed in approximately 86% of human breast tumors. The role of Brk in breast pathology is unclear. We expressed a WAP-driven Brk/PTK6 transgene in FVB/n mice, and analyzed mammary glands from wild-type (wt) and transgenic mice after forced weaning. Western blotting and immunohistochemistry (IHC) studies were conducted to visualize markers of mammary gland involution, cell proliferation and apoptosis, as well as Brk, STAT3, and activated p38 mitogen-activated protein kinase (MAPK) in mammary tissues and tumors from WAP-Brk mice. Human (HMEC) or mouse (HC11) mammary epithelial cells were stably or transiently transfected with Brk cDNA to assay p38 MAPK signaling and cell survival in suspensi Protein tyrosine kinases (PTKs) are frequently overexpressed and/or activated in human malignancies, and regulate cancer cell proliferation, cellular survival, and migration. As such, they have become promising molecular targets for new therapies. The non-receptor PTK termed breast tumor kinase (Brk/PTK6) is overexpressed in approximately 86% of human breast tumors. The role of Brk in breast pathology is unclear. We expressed a WAP-driven Brk/PTK6 transgene in FVB/n mice, and analyzed mammary glands from wild-type (wt) and transgenic mice after forced weaning. Western blotting and immunohistochemistry (IHC) studies were conducted to visualize markers of mammary gland involution, cell proliferation and apoptosis, as well as Brk, STAT3, and activated p38 mitogen-activated protein kinase (MAPK) in mammary tissues and tumors from WAP-Brk mice. Human (HMEC) or mouse (HC11) mammary epithelial cells were stably or transiently transfected with Brk cDNA to assay p38 MAPK signaling and cell survival in suspensi
dcterms:title
Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK
skos:prefLabel
Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK
skos:notation
RIV/00216208:11120/11:00003582!RIV12-MSM-11120___
n12:predkladatel
n13:orjk%3A11120
n3:aktivita
n14:N
n3:aktivity
N
n3:cisloPeriodika
5
n3:dodaniDat
n9:2012
n3:domaciTvurceVysledku
n11:2483327
n3:druhVysledku
n15:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
210369
n3:idVysledku
RIV/00216208:11120/11:00003582
n3:jazykVysledku
n20:eng
n3:klicovaSlova
Protein-Tyrosine Kinase; Breast-Cancer Cells; Epithelial-Cells; Gastrointestinal-Tract; Transgenic Mice; Brk; Receptor; Signal; Carcinoma; Migration
n3:klicoveSlovo
n4:Breast-Cancer%20Cells n4:Brk n4:Signal n4:Protein-Tyrosine%20Kinase n4:Migration n4:Carcinoma n4:Gastrointestinal-Tract n4:Transgenic%20Mice n4:Receptor n4:Epithelial-Cells
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[EEB784A4F68C]
n3:nazevZdroje
Breast Cancer Research
n3:obor
n18:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
8
n3:rokUplatneniVysledku
n9:2011
n3:svazekPeriodika
13
n3:tvurceVysledku
Lofgren, K. A. Housa, Daniel
n3:wos
000298928100005
s:issn
1465-542X
s:numberOfPages
17
n7:doi
10.1186/bcr2946
n19:organizacniJednotka
11120