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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F11%3A00003507%21RIV12-MSM-11120___
rdf:type
skos:Concept n15:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1016/j.psychres.2010.10.033
dcterms:description
The interaction between polarity at onset (PAO) and age at onset (AAO) appears to be important for interpreting results of previous analyses of AAO in bipolar disorder (BD). Using an admixture analysis, we examined independently the distributions of age at first depressive and hypomanic/manic episodes in 379 BD I and II patients. Subsequently, we examined the association of PAO and AAO with specific clinical variables, using parametric and nonparametric analyses. Both depressive and manic onsets showed bimodal distributions. For depressive episodes, the means were: 18.5 +/- 4.1 (early onset) and 33.6 +/- 10.4 (late onset) years; and for manic episodes 18.9 +/- 3.3 (early onset) and 34.8 +/- 10.9 (late onset) years. For the overall AAO the best fit was for a mixture of three lognormal distributions (mean S.D.): 15.5 +/- 2.0, 22.8 +/- 4.6, and 36.1 +/- 10.1 years. Overall, an early onset was significantly associated with a chronic course of the disorder, a stronger family history of affective disorder, The interaction between polarity at onset (PAO) and age at onset (AAO) appears to be important for interpreting results of previous analyses of AAO in bipolar disorder (BD). Using an admixture analysis, we examined independently the distributions of age at first depressive and hypomanic/manic episodes in 379 BD I and II patients. Subsequently, we examined the association of PAO and AAO with specific clinical variables, using parametric and nonparametric analyses. Both depressive and manic onsets showed bimodal distributions. For depressive episodes, the means were: 18.5 +/- 4.1 (early onset) and 33.6 +/- 10.4 (late onset) years; and for manic episodes 18.9 +/- 3.3 (early onset) and 34.8 +/- 10.9 (late onset) years. For the overall AAO the best fit was for a mixture of three lognormal distributions (mean S.D.): 15.5 +/- 2.0, 22.8 +/- 4.6, and 36.1 +/- 10.1 years. Overall, an early onset was significantly associated with a chronic course of the disorder, a stronger family history of affective disorder,
dcterms:title
An admixture analysis of the age at index episodes in bipolar disorder An admixture analysis of the age at index episodes in bipolar disorder
skos:prefLabel
An admixture analysis of the age at index episodes in bipolar disorder An admixture analysis of the age at index episodes in bipolar disorder
skos:notation
RIV/00216208:11120/11:00003507!RIV12-MSM-11120___
n15:predkladatel
n16:orjk%3A11120
n3:aktivita
n5:I
n3:aktivity
I
n3:cisloPeriodika
1
n3:dodaniDat
n17:2012
n3:domaciTvurceVysledku
n7:8421382 n7:9731768
n3:druhVysledku
n10:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
185392
n3:idVysledku
RIV/00216208:11120/11:00003507
n3:jazykVysledku
n19:eng
n3:klicovaSlova
onset; bipolar; distributions; index episode; polarity
n3:klicoveSlovo
n9:distributions n9:bipolar n9:polarity n9:index%20episode n9:onset
n3:kodStatuVydavatele
IE - Irsko
n3:kontrolniKodProRIV
[59CCA99AAEE9]
n3:nazevZdroje
Psychiatry Research
n3:obor
n20:FL
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
8
n3:rokUplatneniVysledku
n17:2011
n3:svazekPeriodika
188
n3:tvurceVysledku
Alda, Martin Růžičková, Martina Ortiz, Abigail
n3:wos
000291834900007
s:issn
0165-1781
s:numberOfPages
6
n13:doi
10.1016/j.psychres.2010.10.033
n14:organizacniJednotka
11120