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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F11%3A00003316%21RIV13-MSM-11120___
rdf:type
n5:Vysledek skos:Concept
dcterms:description
Repeated warm laser stimuli produce a progressive increase of the sensation of warmth and heat and eventually that of a burning pain. The pain resulting from repetitive warm stimuli is mediated by summated C fibre responses. To shed more light on the cortical changes associated with pain during repeated subnoxious warm stimution, we analysed magnetoencephalographic (MEG) evoked fields in eleven subjects during application of repetitive warm laser stimuli to the dorsum of the right hand. One set of stimuli encompassed 10 laser pulses occurring at 2.5 s intervals. Parameters of laser stimulation were optimised to elicit a pleasant warm sensation upon a single stimulus with a rise of skin temperature after repeated stimulation not exceeding the threshold of C mechano-heat fibres. Subjects reported a progressive increase of the intensity of heat and burning pain during repeated laser stimulation in spite of only mild (4.8 degrees C) increase of skin temperature from the first stimulus to the tenth stimulus. The mean reaction time, evaluated in six subjects, was 1.33 s, confirming involvement of C fibres. The neuromagnetic fields were modelled by five equivalent source dipoles located in the occipital cortex, cerebellum, posterior cingulate cortex, and left and right operculo-insular cortex. The only component showing statistically significant changes during repetitive laser stimulation was the late component of the contralateral operculo-insular source peaking at 1.05 s after stimulus onset. The amplitude increases of the late component of the contralateral operculo-insular source dipole correlated with the subjects' numerical ratings of warmth and pain. Results point to a pivotal role of the contralateral operculo-insular region in processing of C-fibre mediated pain during repeated subnoxious laser stimulation. Repeated warm laser stimuli produce a progressive increase of the sensation of warmth and heat and eventually that of a burning pain. The pain resulting from repetitive warm stimuli is mediated by summated C fibre responses. To shed more light on the cortical changes associated with pain during repeated subnoxious warm stimution, we analysed magnetoencephalographic (MEG) evoked fields in eleven subjects during application of repetitive warm laser stimuli to the dorsum of the right hand. One set of stimuli encompassed 10 laser pulses occurring at 2.5 s intervals. Parameters of laser stimulation were optimised to elicit a pleasant warm sensation upon a single stimulus with a rise of skin temperature after repeated stimulation not exceeding the threshold of C mechano-heat fibres. Subjects reported a progressive increase of the intensity of heat and burning pain during repeated laser stimulation in spite of only mild (4.8 degrees C) increase of skin temperature from the first stimulus to the tenth stimulus. The mean reaction time, evaluated in six subjects, was 1.33 s, confirming involvement of C fibres. The neuromagnetic fields were modelled by five equivalent source dipoles located in the occipital cortex, cerebellum, posterior cingulate cortex, and left and right operculo-insular cortex. The only component showing statistically significant changes during repetitive laser stimulation was the late component of the contralateral operculo-insular source peaking at 1.05 s after stimulus onset. The amplitude increases of the late component of the contralateral operculo-insular source dipole correlated with the subjects' numerical ratings of warmth and pain. Results point to a pivotal role of the contralateral operculo-insular region in processing of C-fibre mediated pain during repeated subnoxious laser stimulation.
dcterms:title
Cortical Activation Changes during Repeated Laser Stimulation: A Magnetoencephalographic Study Cortical Activation Changes during Repeated Laser Stimulation: A Magnetoencephalographic Study
skos:prefLabel
Cortical Activation Changes during Repeated Laser Stimulation: A Magnetoencephalographic Study Cortical Activation Changes during Repeated Laser Stimulation: A Magnetoencephalographic Study
skos:notation
RIV/00216208:11120/11:00003316!RIV13-MSM-11120___
n5:predkladatel
n6:orjk%3A11120
n3:aktivita
n7:Z n7:P
n3:aktivity
P(1M0517), Z(MSM0021620816)
n3:cisloPeriodika
5
n3:dodaniDat
n12:2013
n3:domaciTvurceVysledku
n14:9172955
n3:druhVysledku
n10:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
192085
n3:idVysledku
RIV/00216208:11120/11:00003316
n3:jazykVysledku
n15:eng
n3:klicovaSlova
Human Brain; Brief Contact; Hz Oscillations; Heat Stimulation; Central Sensitization; Spinal-Cord; Fibromyalgia Patients; Temporal Summation; 2nd Pain Sensations; Somatosensory-Evoked Potentials
n3:klicoveSlovo
n8:2nd%20Pain%20Sensations n8:Hz%20Oscillations n8:Somatosensory-Evoked%20Potentials n8:Temporal%20Summation n8:Brief%20Contact n8:Human%20Brain n8:Central%20Sensitization n8:Spinal-Cord n8:Fibromyalgia%20Patients n8:Heat%20Stimulation
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[ADA606F7C9B9]
n3:nazevZdroje
PLoS One
n3:obor
n9:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
3
n3:projekt
n20:1M0517
n3:rokUplatneniVysledku
n12:2011
n3:svazekPeriodika
6
n3:tvurceVysledku
Stančák, Andrej
n3:wos
000290440200023
n3:zamer
n16:MSM0021620816
s:issn
1932-6203
s:numberOfPages
10
n17:doi
10.1371/journal.pone.0019744
n21:organizacniJednotka
11120