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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F11%3A00003234%21RIV12-MSM-11120___
rdf:type
skos:Concept n11:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1159/000329954
dcterms:description
In this study we have tested the effect of unsaturated fatty acids on the proapoptotic effects of saturated fatty acids in the human pancreatic beta-cells NES2Y. We found that unsaturated palmitoleic and oleic acid at a concentration of 0.2 mM and higher are able to completely inhibit the proapoptotic effect of their counterpart saturated palmitic and stearic acid at a concentration of 1 mM. Apoptosis induced by stearic acid was associated with significant activation of caspase-6, -7, -9, -2 and -8, but not with significant activation of caspase-3. The activation of caspases was blocked by coincubation with oleic acid. Stearic acid treatment was not associated with a significant change in mitochondrial membrane potential, reactive oxygen species level and with cytochrome c release from mitochondria. Furthermore, stearic acid treatment was not associated with changes in p21(WAF1/CIP1), PIDD, Fas receptor and Fas ligand expression. However, we detected endoplasmic reticulum (ER) stress markers, i.e. a s In this study we have tested the effect of unsaturated fatty acids on the proapoptotic effects of saturated fatty acids in the human pancreatic beta-cells NES2Y. We found that unsaturated palmitoleic and oleic acid at a concentration of 0.2 mM and higher are able to completely inhibit the proapoptotic effect of their counterpart saturated palmitic and stearic acid at a concentration of 1 mM. Apoptosis induced by stearic acid was associated with significant activation of caspase-6, -7, -9, -2 and -8, but not with significant activation of caspase-3. The activation of caspases was blocked by coincubation with oleic acid. Stearic acid treatment was not associated with a significant change in mitochondrial membrane potential, reactive oxygen species level and with cytochrome c release from mitochondria. Furthermore, stearic acid treatment was not associated with changes in p21(WAF1/CIP1), PIDD, Fas receptor and Fas ligand expression. However, we detected endoplasmic reticulum (ER) stress markers, i.e. a s
dcterms:title
Inhibitory effect of unsaturated fatty acids on saturated fatty acid-induced apoptosis in human pancreatic beta-Cells: Activation of caspases and ER stress induction Inhibitory effect of unsaturated fatty acids on saturated fatty acid-induced apoptosis in human pancreatic beta-Cells: Activation of caspases and ER stress induction
skos:prefLabel
Inhibitory effect of unsaturated fatty acids on saturated fatty acid-induced apoptosis in human pancreatic beta-Cells: Activation of caspases and ER stress induction Inhibitory effect of unsaturated fatty acids on saturated fatty acid-induced apoptosis in human pancreatic beta-Cells: Activation of caspases and ER stress induction
skos:notation
RIV/00216208:11120/11:00003234!RIV12-MSM-11120___
n11:predkladatel
n20:orjk%3A11120
n3:aktivita
n14:Z n14:S
n3:aktivity
S, Z(MSM0021620814)
n3:cisloPeriodika
5
n3:dodaniDat
n9:2012
n3:domaciTvurceVysledku
n5:1758330 n5:4215036
n3:druhVysledku
n17:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
204858
n3:idVysledku
RIV/00216208:11120/11:00003234
n3:jazykVysledku
n21:eng
n3:klicovaSlova
fatty acids; apoptosis; beta-cell; caspases; endoplasmic reticulum stress
n3:klicoveSlovo
n6:endoplasmic%20reticulum%20stress n6:beta-cell n6:caspases n6:fatty%20acids n6:apoptosis
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[383B06F07C4E]
n3:nazevZdroje
Cellular Physiology and Biochemistry
n3:obor
n18:EB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n9:2011
n3:svazekPeriodika
27
n3:tvurceVysledku
Němcová-Fürstová, Vlasta James, Roger F. L. Kovář, Jan
n3:wos
000291754000012
n3:zamer
n19:MSM0021620814
s:issn
1015-8987
s:numberOfPages
14
n8:doi
10.1159/000329954
n16:organizacniJednotka
11120