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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F11%3A00003190%21RIV12-MZ0-11120___
rdf:type
skos:Concept n12:Vysledek
rdfs:seeAlso
http://iv.iiarjournals.org/content/25/6/849.abstract
dcterms:description
Studies over the past decade have clearly shown that s.c. implant of primary and cultured tumor cells rarely leads to the occurrence of metastatic disease. Orthotopic transplantation of cell suspensions, surgical orthotopic implantation (SOI) of cancer tissue fragments resulted in metastases in many cancer types reaching 100% successful rate. We compared two metastatic models - heterotopic model of Lewis lung cancer and orthotopic B16 mouse melanoma. Both models were syngeneic with high metastatic ratio in C57BL/6 mice after transplantation of cancer cells, by injection into subcutaneous region of mice tail and without surgical intervention. The conclusion is that the localisation of cancer cell injection is a crucial condition for metastatic potential. The site with 100% haematogenous and lymph metastasis rate, after simple injection of cancer cells only, has been defined in mice, without dependence on the genetically predisposition and tumor cell line. Studies over the past decade have clearly shown that s.c. implant of primary and cultured tumor cells rarely leads to the occurrence of metastatic disease. Orthotopic transplantation of cell suspensions, surgical orthotopic implantation (SOI) of cancer tissue fragments resulted in metastases in many cancer types reaching 100% successful rate. We compared two metastatic models - heterotopic model of Lewis lung cancer and orthotopic B16 mouse melanoma. Both models were syngeneic with high metastatic ratio in C57BL/6 mice after transplantation of cancer cells, by injection into subcutaneous region of mice tail and without surgical intervention. The conclusion is that the localisation of cancer cell injection is a crucial condition for metastatic potential. The site with 100% haematogenous and lymph metastasis rate, after simple injection of cancer cells only, has been defined in mice, without dependence on the genetically predisposition and tumor cell line.
dcterms:title
Tail spontaneous metastatic mouse model: comparison of metastatic potential of orthotopic and heterotopic models imaged by GFP and RFP protein Tail spontaneous metastatic mouse model: comparison of metastatic potential of orthotopic and heterotopic models imaged by GFP and RFP protein
skos:prefLabel
Tail spontaneous metastatic mouse model: comparison of metastatic potential of orthotopic and heterotopic models imaged by GFP and RFP protein Tail spontaneous metastatic mouse model: comparison of metastatic potential of orthotopic and heterotopic models imaged by GFP and RFP protein
skos:notation
RIV/00216208:11120/11:00003190!RIV12-MZ0-11120___
n12:predkladatel
n13:orjk%3A11120
n3:aktivita
n15:P
n3:aktivity
P(ME10045), P(NS9976)
n3:cisloPeriodika
6
n3:dodaniDat
n16:2012
n3:domaciTvurceVysledku
n7:6819362 n7:5279208 n7:2394685 n7:5704995 n7:9313605
n3:druhVysledku
n11:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n20:predkladatel
n3:idSjednocenehoVysledku
234154
n3:idVysledku
RIV/00216208:11120/11:00003190
n3:jazykVysledku
n9:eng
n3:klicovaSlova
spontaneous metastasis; tail metastasis model; lymph node; Lewis lung cancer; metastasis; tumor; GFP
n3:klicoveSlovo
n4:Lewis%20lung%20cancer n4:GFP n4:spontaneous%20metastasis n4:tumor n4:tail%20metastasis%20model n4:metastasis n4:lymph%20node
n3:kodStatuVydavatele
GR - Řecká republika
n3:kontrolniKodProRIV
[9AAB155F2BD3]
n3:nazevZdroje
In Vivo
n3:obor
n8:EB
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
6
n3:projekt
n5:ME10045 n5:NS9976
n3:rokUplatneniVysledku
n16:2011
n3:svazekPeriodika
25
n3:tvurceVysledku
Kološtová, Katarína Pintérová, Daniela Gürlich, Robert Boubelík, Michael Bobek, Vladimír
n3:wos
000296306800002
s:issn
0258-851X
s:numberOfPages
4
n17:organizacniJednotka
11120