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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F11%3A00003174%21RIV12-MZ0-11120___
rdf:type
skos:Concept n13:Vysledek
dcterms:description
There are only few studies that examine the effect of prenatal methamphetamine (MA) exposure on the sensitivity to the same drug and the drug-seeking behavior in adulthood. The aim of the present study was to examine the effect of prenatal MA exposure on exploratory behavior and nociception with respect to challenge dose of the same drug. Mothers of the tested offspring received a daily injection of MA (5 mg/kg) or saline throughout the gestation period. Adult male offspring (prenatally MA- or saline-exposed) were divided to groups with challenge dose of MA (1 mg/kg) or saline. A modified Open field test (Laboras) was used to examine behavior in unknown environment. Plantar test was used to measure nociception on forelimbs, hind limbs, and the tail. Conditioned place preference (CPP) test was used to examine drug-seeking behavior. Our results in Laboras demonstrated that prenatal MA exposure sensitized the animals to the challenge dose of MA. There are only few studies that examine the effect of prenatal methamphetamine (MA) exposure on the sensitivity to the same drug and the drug-seeking behavior in adulthood. The aim of the present study was to examine the effect of prenatal MA exposure on exploratory behavior and nociception with respect to challenge dose of the same drug. Mothers of the tested offspring received a daily injection of MA (5 mg/kg) or saline throughout the gestation period. Adult male offspring (prenatally MA- or saline-exposed) were divided to groups with challenge dose of MA (1 mg/kg) or saline. A modified Open field test (Laboras) was used to examine behavior in unknown environment. Plantar test was used to measure nociception on forelimbs, hind limbs, and the tail. Conditioned place preference (CPP) test was used to examine drug-seeking behavior. Our results in Laboras demonstrated that prenatal MA exposure sensitized the animals to the challenge dose of MA.
dcterms:title
Impact of prenatal methamphetamine exposure on the sensitivity to the same drug in adult male rats Impact of prenatal methamphetamine exposure on the sensitivity to the same drug in adult male rats
skos:prefLabel
Impact of prenatal methamphetamine exposure on the sensitivity to the same drug in adult male rats Impact of prenatal methamphetamine exposure on the sensitivity to the same drug in adult male rats
skos:notation
RIV/00216208:11120/11:00003174!RIV12-MZ0-11120___
n13:predkladatel
n14:orjk%3A11120
n3:aktivita
n10:P
n3:aktivity
P(GA305/09/0126), P(GAP303/10/0580), P(NS10509)
n3:cisloPeriodika
2
n3:dodaniDat
n8:2012
n3:domaciTvurceVysledku
n6:6841910 n6:1027980 n6:6877141 n6:6894577 n6:1128574
n3:druhVysledku
n12:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
203701
n3:idVysledku
RIV/00216208:11120/11:00003174
n3:jazykVysledku
n5:eng
n3:klicovaSlova
prenatal drug exposure; methamphetamine; Open field; Plantar test: Conditioned place preference; locomotion; nociception; drug-seeking behavior
n3:klicoveSlovo
n4:prenatal%20drug%20exposure n4:drug-seeking%20behavior n4:nociception n4:Open%20field n4:Plantar%20test%3A%20Conditioned%20place%20preference n4:locomotion n4:methamphetamine
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[5FCD997EDE5E]
n3:nazevZdroje
Prague Medical Report
n3:obor
n11:EB
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n16:GA305%2F09%2F0126 n16:GAP303%2F10%2F0580 n16:NS10509
n3:rokUplatneniVysledku
n8:2011
n3:svazekPeriodika
112
n3:tvurceVysledku
Šlamberová, Romana Schutová, Barbora Pometlová, Marie Yamamotová, Anna Hrubá, Lenka
s:issn
1214-6994
s:numberOfPages
13
n18:organizacniJednotka
11120