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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F11%3A00003158%21RIV12-MZ0-11120___
rdf:type
skos:Concept n14:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1016/j.leukres.2010.12.016
dcterms:description
TP53 plays a pivotal role in the process of DNA repair and apoptosis. In 10-20% of patients with chronic lymphocytic leukemia (CLL), the TP53 pathway is affected. In this study, we analyzed the TP53 mutation status in 2435 consecutive CLL samples, including 1287 diagnostic samples and 1148 samples during follow-up, using FASAY (Functional Analysis of Separated Alleles in Yeast) and direct sequencing. In a cohort of 1287 diagnostic CLL samples, we identified 237 cases with TP53 variants, including mutations, temperature-sensitive variants, deletions, insertions and aberrant splicing variants (18.4%). In 1148 follow-up samples, no TP53 clonal evolution was observed. TP53 plays a pivotal role in the process of DNA repair and apoptosis. In 10-20% of patients with chronic lymphocytic leukemia (CLL), the TP53 pathway is affected. In this study, we analyzed the TP53 mutation status in 2435 consecutive CLL samples, including 1287 diagnostic samples and 1148 samples during follow-up, using FASAY (Functional Analysis of Separated Alleles in Yeast) and direct sequencing. In a cohort of 1287 diagnostic CLL samples, we identified 237 cases with TP53 variants, including mutations, temperature-sensitive variants, deletions, insertions and aberrant splicing variants (18.4%). In 1148 follow-up samples, no TP53 clonal evolution was observed.
dcterms:title
A comprehensive study of TP53 mutations in chronic lymphocytic leukemia: Analysis of 1287 diagnostic and 1148 follow-up CLL samples A comprehensive study of TP53 mutations in chronic lymphocytic leukemia: Analysis of 1287 diagnostic and 1148 follow-up CLL samples
skos:prefLabel
A comprehensive study of TP53 mutations in chronic lymphocytic leukemia: Analysis of 1287 diagnostic and 1148 follow-up CLL samples A comprehensive study of TP53 mutations in chronic lymphocytic leukemia: Analysis of 1287 diagnostic and 1148 follow-up CLL samples
skos:notation
RIV/00216208:11120/11:00003158!RIV12-MZ0-11120___
n14:predkladatel
n22:orjk%3A11120
n3:aktivita
n6:Z n6:P n6:I
n3:aktivity
I, P(NS9652), Z(MZ0FNHK2005)
n3:cisloPeriodika
7
n3:dodaniDat
n4:2012
n3:domaciTvurceVysledku
n15:3541282 n15:4524195 n15:4684834 n15:1463268
n3:druhVysledku
n16:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
183717
n3:idVysledku
RIV/00216208:11120/11:00003158
n3:jazykVysledku
n12:eng
n3:klicovaSlova
CLL; FASAY; TP53
n3:klicoveSlovo
n13:TP53 n13:FASAY n13:CLL
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[7943846460D3]
n3:nazevZdroje
Leukemia Research
n3:obor
n10:FD
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
13
n3:projekt
n8:NS9652
n3:rokUplatneniVysledku
n4:2011
n3:svazekPeriodika
357
n3:tvurceVysledku
Žejšková, Lenka Jančušková, Tereza Peková, Soňa Kozák, Tomáš
n3:wos
000291470800028
n3:zamer
n19:MZ0FNHK2005
s:issn
0145-2126
s:numberOfPages
10
n21:doi
10.1016/j.leukres.2010.12.016
n20:organizacniJednotka
11120