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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F11%3A00003156%21RIV12-MZ0-11120___
rdf:type
n3:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1007/s10637-009-9368-8
dcterms:description
The aim of the study is to compare the effects of new fluorinated taxanes SB-T-12851, SB-T-12852, SB-T-12853, and SB-T-12854 with those of the classical taxane paclitaxel and novel non-fluorinated taxane SB-T-1216 on cancer cells. Paclitaxel -sensitive MDA-MB-435 and paclitaxel-resistant NCI/ADR-RES human cancer cell lines were used. The new fluorinated taxanes appear to use the same or similar mechanisms of cell death induction as compared with SB-T-1216 and paclitaxel. New fluorinated and non-fluorinated taxanes are more effective against drug-resistant cancer cells than paclitaxel. The aim of the study is to compare the effects of new fluorinated taxanes SB-T-12851, SB-T-12852, SB-T-12853, and SB-T-12854 with those of the classical taxane paclitaxel and novel non-fluorinated taxane SB-T-1216 on cancer cells. Paclitaxel -sensitive MDA-MB-435 and paclitaxel-resistant NCI/ADR-RES human cancer cell lines were used. The new fluorinated taxanes appear to use the same or similar mechanisms of cell death induction as compared with SB-T-1216 and paclitaxel. New fluorinated and non-fluorinated taxanes are more effective against drug-resistant cancer cells than paclitaxel.
dcterms:title
Cell death induced by novel fluorinated taxanes in drug-sensitive and drug-resistant cancer cells Cell death induced by novel fluorinated taxanes in drug-sensitive and drug-resistant cancer cells
skos:prefLabel
Cell death induced by novel fluorinated taxanes in drug-sensitive and drug-resistant cancer cells Cell death induced by novel fluorinated taxanes in drug-sensitive and drug-resistant cancer cells
skos:notation
RIV/00216208:11120/11:00003156!RIV12-MZ0-11120___
n3:predkladatel
n10:orjk%3A11120
n5:aktivita
n16:P
n5:aktivity
P(GA301/09/0362), P(NR9426)
n5:cisloPeriodika
3
n5:dodaniDat
n18:2012
n5:domaciTvurceVysledku
n11:7436505 n11:1116339 n11:4215036 n11:1758330
n5:druhVysledku
n17:J
n5:duvernostUdaju
n19:S
n5:entitaPredkladatele
n12:predkladatel
n5:idSjednocenehoVysledku
189374
n5:idVysledku
RIV/00216208:11120/11:00003156
n5:jazykVysledku
n13:eng
n5:klicovaSlova
Cell death; paclitaxel; taxanes; fluorinated taxanes; caspases
n5:klicoveSlovo
n9:fluorinated%20taxanes n9:paclitaxel n9:taxanes n9:caspases n9:Cell%20death
n5:kodStatuVydavatele
NL - Nizozemsko
n5:kontrolniKodProRIV
[FA520978620E]
n5:nazevZdroje
Investigational New Drugs
n5:obor
n6:CE
n5:pocetDomacichTvurcuVysledku
4
n5:pocetTvurcuVysledku
7
n5:projekt
n14:GA301%2F09%2F0362 n14:NR9426
n5:rokUplatneniVysledku
n18:2011
n5:svazekPeriodika
29
n5:tvurceVysledku
Kovář, Jan Neubauerová, Jitka Němcová-Fürstová, Vlasta Vobořilová, Jana
n5:wos
000289526400002
s:issn
0167-6997
s:numberOfPages
13
n4:doi
10.1007/s10637-009-9368-8
n21:organizacniJednotka
11120