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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F11%3A00002949%21RIV12-MSM-11120___
rdf:type
skos:Concept n10:Vysledek
rdfs:seeAlso
http://lge.lf1.cuni.cz/pdf/p2.pdf
dcterms:description
The essential role of MCM 2-7 proteins in the initiation of DNA replication in all eukaryotes is well known. Their role in replication elongation is supported by numerous studies, but there is still a knowledge gap in this respect. Even though biochemical studies have established an association of MCM proteins with replication forks, previous immunofluorescence studies in mammalian cells have suggested that MCM 2-7 proteins are displaced after replication initiation from sites of DNA replication. Therefore, we used a robust statistical method to more precisely analyse immunofluorescence localization of MCM 2 proteins with respect to the DNA replication foci. We show that despite the predominantly different localization of MCM 2 and replication signals, there is still a small but significant fraction of MCM 2 proteins that co-localize with DNA replication foci during most of S phase. The fluorescence localization of the MCM 2 proteins and DNA replication may thus reflect an active function of MCM 2 pro The essential role of MCM 2-7 proteins in the initiation of DNA replication in all eukaryotes is well known. Their role in replication elongation is supported by numerous studies, but there is still a knowledge gap in this respect. Even though biochemical studies have established an association of MCM proteins with replication forks, previous immunofluorescence studies in mammalian cells have suggested that MCM 2-7 proteins are displaced after replication initiation from sites of DNA replication. Therefore, we used a robust statistical method to more precisely analyse immunofluorescence localization of MCM 2 proteins with respect to the DNA replication foci. We show that despite the predominantly different localization of MCM 2 and replication signals, there is still a small but significant fraction of MCM 2 proteins that co-localize with DNA replication foci during most of S phase. The fluorescence localization of the MCM 2 proteins and DNA replication may thus reflect an active function of MCM 2 pro
dcterms:title
A Fraction of MCM 2 Proteins Remain Associated with Replication Foci During a Major Part of S Phase A Fraction of MCM 2 Proteins Remain Associated with Replication Foci During a Major Part of S Phase
skos:prefLabel
A Fraction of MCM 2 Proteins Remain Associated with Replication Foci During a Major Part of S Phase A Fraction of MCM 2 Proteins Remain Associated with Replication Foci During a Major Part of S Phase
skos:notation
RIV/00216208:11120/11:00002949!RIV12-MSM-11120___
n10:predkladatel
n21:orjk%3A11120
n4:aktivita
n12:I n12:S n12:P n12:Z
n4:aktivity
I, P(LC535), S, Z(MSM0021620806)
n4:cisloPeriodika
1
n4:dodaniDat
n6:2012
n4:domaciTvurceVysledku
n7:7891687
n4:druhVysledku
n15:J
n4:duvernostUdaju
n19:S
n4:entitaPredkladatele
n17:predkladatel
n4:idSjednocenehoVysledku
183802
n4:idVysledku
RIV/00216208:11120/11:00002949
n4:jazykVysledku
n9:eng
n4:klicovaSlova
DNA replication; MCM proteins; immunofluorescence; replication foci; MCM paradox
n4:klicoveSlovo
n11:MCM%20paradox n11:MCM%20proteins n11:immunofluorescence n11:DNA%20replication n11:replication%20foci
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[97FD4CE1056D]
n4:nazevZdroje
Folia Biologica
n4:obor
n18:CE
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
5
n4:projekt
n16:LC535
n4:rokUplatneniVysledku
n6:2011
n4:svazekPeriodika
57
n4:tvurceVysledku
Raška, Otakar Mašata, Martin
n4:wos
000288623700002
n4:zamer
n13:MSM0021620806
s:issn
0015-5500
s:numberOfPages
9
n20:organizacniJednotka
11120