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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F11%3A00002910%21RIV12-MSM-11120___
rdf:type
n9:Vysledek skos:Concept
rdfs:seeAlso
http://www.biomed.cas.cz/physiolres/pdf/60/60_139.pdf
dcterms:description
Adiponectin is an adipokine increasing glucose and fatty acid metabolism and improving insulin sensitivity. The aim of this study was to investigate the role of adiponectin in the regulation of adipocyte lipolysis. Human adipocytes isolated from biopsies obtained during surgical operations from 16 non-obese and 17 obese subjects were incubated with 1) human adiponectin (20 mu g/ml) or 2) 0.5 mM AICAR - activator of AMPK (adenosine monophosphate activated protein kinase). Following these incubations, isoprenaline was added (10(-6) M) to investigate the influence of adiponectin and AICAR on catecholamine-induced lipolysis. Glycerol concentration was measured as lipolysis marker. We observed that adiponectin suppressed spontaneous lipolysis by 21 % and isoprenaline-induced lipolysis by 14 % in non-obese subjects. These effects were not detectable in obese individuals, but statistically significant differences in the effect of adiponectin between obese and non-obese were not revealed by two way ANOVA test Adiponectin is an adipokine increasing glucose and fatty acid metabolism and improving insulin sensitivity. The aim of this study was to investigate the role of adiponectin in the regulation of adipocyte lipolysis. Human adipocytes isolated from biopsies obtained during surgical operations from 16 non-obese and 17 obese subjects were incubated with 1) human adiponectin (20 mu g/ml) or 2) 0.5 mM AICAR - activator of AMPK (adenosine monophosphate activated protein kinase). Following these incubations, isoprenaline was added (10(-6) M) to investigate the influence of adiponectin and AICAR on catecholamine-induced lipolysis. Glycerol concentration was measured as lipolysis marker. We observed that adiponectin suppressed spontaneous lipolysis by 21 % and isoprenaline-induced lipolysis by 14 % in non-obese subjects. These effects were not detectable in obese individuals, but statistically significant differences in the effect of adiponectin between obese and non-obese were not revealed by two way ANOVA test
dcterms:title
Adiponectin inhibits spontaneous and catecholamine-induced lipolysis in human adipocytes of non-obese subjects through AMPK-dependent mechanisms Adiponectin inhibits spontaneous and catecholamine-induced lipolysis in human adipocytes of non-obese subjects through AMPK-dependent mechanisms
skos:prefLabel
Adiponectin inhibits spontaneous and catecholamine-induced lipolysis in human adipocytes of non-obese subjects through AMPK-dependent mechanisms Adiponectin inhibits spontaneous and catecholamine-induced lipolysis in human adipocytes of non-obese subjects through AMPK-dependent mechanisms
skos:notation
RIV/00216208:11120/11:00002910!RIV12-MSM-11120___
n9:predkladatel
n16:orjk%3A11120
n3:aktivita
n12:R
n3:aktivity
R
n3:cisloPeriodika
1
n3:dodaniDat
n17:2012
n3:domaciTvurceVysledku
n6:3966577 n6:9394915 n6:6395996 n6:1097288 n6:9313605 n6:7508808 n6:9021000 n6:5479851 n6:4377974
n3:druhVysledku
n11:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
184655
n3:idVysledku
RIV/00216208:11120/11:00002910
n3:jazykVysledku
n8:eng
n3:klicovaSlova
obesity; Adiponectin; lipolysis; adipose tissue; AMPK
n3:klicoveSlovo
n4:Adiponectin n4:adipose%20tissue n4:obesity n4:AMPK n4:lipolysis
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[B4C77D2FC198]
n3:nazevZdroje
Physiological Research
n3:obor
n18:ED
n3:pocetDomacichTvurcuVysledku
9
n3:pocetTvurcuVysledku
10
n3:rokUplatneniVysledku
n17:2011
n3:svazekPeriodika
60
n3:tvurceVysledku
Kološtová, Katarína Vedral, Tomáš Dušková, Markéta Wedellová, Zuzana Kováčová, Zuzana Brož, Jan Štich, Vladimír Dietrich, Jon Polák, Jan Šiklová-Vítková, Michaela
n3:wos
000288563800013
s:issn
0862-8408
s:numberOfPages
10
n14:organizacniJednotka
11120