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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F11%3A00002462%21RIV12-MZ0-11120___
rdf:type
n13:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1111/j.1600-0463.2010.02685.x
dcterms:description
Epstein-Barr virus (EBV) is associated with approximately one-third of Hodgkin lymphoma (HL) cases. EBV-DNA is often present in the plasma and whole blood of EBV-associated HL patients. However, the significance of EBV-DNA monitoring is debated. In a cohort of 165 adult HL patients, EBV-DNA viral load was prospectively monitored both in the plasma and whole blood. Diagnostic tissue samples of all patients were histologically reviewed; in 72% nodular sclerosis was detected, 24% presented with mixed cellularity (MC), and 5% had other type of HL. Tissues from 150 patients were also analyzed for the presence of latent EBV infection using in situ hybridization for EBV-encoded RNA (EBER) and immunohistochemistry for latent membrane protein (LMP1). Using these methods, 29 (19%) patients were classified as EBV positive. Using real-time quantitative PCR, 22 (76%) of EBV-positive HL patients had detectable EBV-DNA in the plasma and 19 (66%) patients in whole blood prior to therapy. Epstein-Barr virus (EBV) is associated with approximately one-third of Hodgkin lymphoma (HL) cases. EBV-DNA is often present in the plasma and whole blood of EBV-associated HL patients. However, the significance of EBV-DNA monitoring is debated. In a cohort of 165 adult HL patients, EBV-DNA viral load was prospectively monitored both in the plasma and whole blood. Diagnostic tissue samples of all patients were histologically reviewed; in 72% nodular sclerosis was detected, 24% presented with mixed cellularity (MC), and 5% had other type of HL. Tissues from 150 patients were also analyzed for the presence of latent EBV infection using in situ hybridization for EBV-encoded RNA (EBER) and immunohistochemistry for latent membrane protein (LMP1). Using these methods, 29 (19%) patients were classified as EBV positive. Using real-time quantitative PCR, 22 (76%) of EBV-positive HL patients had detectable EBV-DNA in the plasma and 19 (66%) patients in whole blood prior to therapy.
dcterms:title
Plasma EBV-DNA monitoring in Epstein-Barr virus-positive Hodgkin lymphoma patients Plasma EBV-DNA monitoring in Epstein-Barr virus-positive Hodgkin lymphoma patients
skos:prefLabel
Plasma EBV-DNA monitoring in Epstein-Barr virus-positive Hodgkin lymphoma patients Plasma EBV-DNA monitoring in Epstein-Barr virus-positive Hodgkin lymphoma patients
skos:notation
RIV/00216208:11120/11:00002462!RIV12-MZ0-11120___
n13:predkladatel
n17:orjk%3A11120
n3:aktivita
n8:I n8:S n8:P
n3:aktivity
I, P(NR9166), S
n3:cisloPeriodika
1
n3:dodaniDat
n5:2012
n3:domaciTvurceVysledku
n12:3092364 n12:8675007 n12:1463268 n12:4504992
n3:druhVysledku
n7:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
220504
n3:idVysledku
RIV/00216208:11120/11:00002462
n3:jazykVysledku
n21:eng
n3:klicovaSlova
Hodgkin lymphoma; Epstein-Barr virus; PCR; LMP1; EBER
n3:klicoveSlovo
n10:LMP1 n10:Hodgkin%20lymphoma n10:Epstein-Barr%20virus n10:PCR n10:EBER
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[B1FF8EF62845]
n3:nazevZdroje
APMIS
n3:obor
n14:FD
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
8
n3:projekt
n11:NR9166
n3:rokUplatneniVysledku
n5:2011
n3:svazekPeriodika
119
n3:tvurceVysledku
Kozák, Tomáš Vernerová, Zdeňka Marková, Jana Špaček, Martin
n3:wos
000285153600002
s:issn
0903-4641
s:numberOfPages
7
n19:doi
10.1111/j.1600-0463.2010.02685.x
n18:organizacniJednotka
11120