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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F10%3A43906492%21RIV13-MSM-11120___
rdf:type
skos:Concept n18:Vysledek
dcterms:description
To assess the role of the intravascular ultrasound (IVUS) during implantation of Drug-eluting stents (DES) on long-term outcome in patients with complex coronary artery disease and high clinical risk profile with special attention to the development of late stent thrombosis (LST). Methods: Two hunderd and ten patients were randomly assigned to receive DES either with (N = 105) or without (N = 105) the IVUS guidance. Dual antiplatelet treatment was administered for 6 months in all patients. At 18-month follow-up, the rates of Major adverse cardiac events (MACEs) (death, myocardial infarction, and reintervention) were assessed in both groups with special attention to possible LST. Stent thrombosis was classified according to Academic Research Consortium (ARC). Results: At the 18-month follow-up, there was no significant difference between both groups regarding MACE (11% vs. 12%; P = NS). Stent thrombosis has occurred in four patients (3.8%) in the group with and in 6 patients (5.7%; P = NS) in the group without the IVUS guidance. Conclusions: In our randomized trial we failed to demonstrate the superiority of the IVUS guidance during DES implantation over standard high-pressure postdilatation. However we confirmed worrisome results concerning DES thrombosis after discontinuation of dual antiplatelet-treatment with documented stent thrombosis related events in almost 5% of patients with 50% of mortality in this high-risk clinical scenario. To assess the role of the intravascular ultrasound (IVUS) during implantation of Drug-eluting stents (DES) on long-term outcome in patients with complex coronary artery disease and high clinical risk profile with special attention to the development of late stent thrombosis (LST). Methods: Two hunderd and ten patients were randomly assigned to receive DES either with (N = 105) or without (N = 105) the IVUS guidance. Dual antiplatelet treatment was administered for 6 months in all patients. At 18-month follow-up, the rates of Major adverse cardiac events (MACEs) (death, myocardial infarction, and reintervention) were assessed in both groups with special attention to possible LST. Stent thrombosis was classified according to Academic Research Consortium (ARC). Results: At the 18-month follow-up, there was no significant difference between both groups regarding MACE (11% vs. 12%; P = NS). Stent thrombosis has occurred in four patients (3.8%) in the group with and in 6 patients (5.7%; P = NS) in the group without the IVUS guidance. Conclusions: In our randomized trial we failed to demonstrate the superiority of the IVUS guidance during DES implantation over standard high-pressure postdilatation. However we confirmed worrisome results concerning DES thrombosis after discontinuation of dual antiplatelet-treatment with documented stent thrombosis related events in almost 5% of patients with 50% of mortality in this high-risk clinical scenario.
dcterms:title
Long-term health outcome and mortality evaluation after invasive coronary treatment using drug eluting stents with or without the IVUS guidance: Randomized control trial: HOME DES IVUS Long-term health outcome and mortality evaluation after invasive coronary treatment using drug eluting stents with or without the IVUS guidance: Randomized control trial: HOME DES IVUS
skos:prefLabel
Long-term health outcome and mortality evaluation after invasive coronary treatment using drug eluting stents with or without the IVUS guidance: Randomized control trial: HOME DES IVUS Long-term health outcome and mortality evaluation after invasive coronary treatment using drug eluting stents with or without the IVUS guidance: Randomized control trial: HOME DES IVUS
skos:notation
RIV/00216208:11120/10:43906492!RIV13-MSM-11120___
n3:aktivita
n5:I n5:S n5:V
n3:aktivity
I, S, V
n3:cisloPeriodika
4
n3:dodaniDat
n15:2013
n3:domaciTvurceVysledku
n4:5509750 n4:5283809
n3:druhVysledku
n8:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
268896
n3:idVysledku
RIV/00216208:11120/10:43906492
n3:jazykVysledku
n16:eng
n3:klicovaSlova
Lesions; 6-Month; Risk; Thrombosis; Implantation; Follow-Up; Double-Blind; Artery-Disease; Intravascular Ultrasound Analysis; Bare-Metal Stents
n3:klicoveSlovo
n6:Implantation n6:Double-Blind n6:Intravascular%20Ultrasound%20Analysis n6:Lesions n6:Bare-Metal%20Stents n6:Thrombosis n6:Follow-Up n6:Risk n6:6-Month n6:Artery-Disease
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[93388B157A08]
n3:nazevZdroje
Catheterization and Cardiovascular Interventions
n3:obor
n14:FA
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
8
n3:rokUplatneniVysledku
n15:2010
n3:svazekPeriodika
75
n3:tvurceVysledku
Špaček, Radim Jakabčin, Jozef
n3:wos
000276588600021
s:issn
1522-1946
s:numberOfPages
6
n11:doi
10.1002/ccd.22244
n9:organizacniJednotka
11120