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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F10%3A00002809%21RIV11-MSM-11120___
rdf:type
n6:Vysledek skos:Concept
dcterms:description
Infantile spasms are characterized by age-specific expression of epileptic spasms and hypsarrhythmia and often result in significant cognitive impairment. Other epilepsies or autism often ensue especially in symptomatic IS (SIS). Cortical or subcortical damage, including white matter, have been implicated in the pathogenesis of SIS. To generate a model of SIS, we recreated this pathology by injecting rats with lipopolysaccharide and doxorubicin intracerebrally at postnatal day (P) 3 and with p-chlorophenylalanine intraperitoneally at P5. Spasms occurred between P4 and 13 and were associated with ictal EEG correlates, interictal EEG abnormalities and neurodevelopmental decline. After P9 other seizures, deficits in learning and memory, and autistic-like behaviors (indifference to other rats, increased grooming) were observed. Adrenocorticotropic hormone (ACTH) did not affect spasms. Vigabatrin transiently suppressed spasms at P5. This new model of SIS will be useful to study the neurobiology and treatme Infantile spasms are characterized by age-specific expression of epileptic spasms and hypsarrhythmia and often result in significant cognitive impairment. Other epilepsies or autism often ensue especially in symptomatic IS (SIS). Cortical or subcortical damage, including white matter, have been implicated in the pathogenesis of SIS. To generate a model of SIS, we recreated this pathology by injecting rats with lipopolysaccharide and doxorubicin intracerebrally at postnatal day (P) 3 and with p-chlorophenylalanine intraperitoneally at P5. Spasms occurred between P4 and 13 and were associated with ictal EEG correlates, interictal EEG abnormalities and neurodevelopmental decline. After P9 other seizures, deficits in learning and memory, and autistic-like behaviors (indifference to other rats, increased grooming) were observed. Adrenocorticotropic hormone (ACTH) did not affect spasms. Vigabatrin transiently suppressed spasms at P5. This new model of SIS will be useful to study the neurobiology and treatme
dcterms:title
A model of symptomatic infantile spasms syndrome A model of symptomatic infantile spasms syndrome
skos:prefLabel
A model of symptomatic infantile spasms syndrome A model of symptomatic infantile spasms syndrome
skos:notation
RIV/00216208:11120/10:00002809!RIV11-MSM-11120___
n3:aktivita
n7:S
n3:aktivity
S
n3:cisloPeriodika
3
n3:dodaniDat
n8:2011
n3:domaciTvurceVysledku
n15:2633892
n3:druhVysledku
n9:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
244692
n3:idVysledku
RIV/00216208:11120/10:00002809
n3:jazykVysledku
n13:eng
n3:klicovaSlova
Infantile spasms; West syndrome; Autism; Animal model; Epilepsy; Lipopolysaccharide; Doxorubicin; p-Chlorophenylalanine; Neonatal rat
n3:klicoveSlovo
n4:Doxorubicin n4:Neonatal%20rat n4:Autism n4:West%20syndrome n4:p-Chlorophenylalanine n4:Animal%20model n4:Lipopolysaccharide n4:Epilepsy n4:Infantile%20spasms
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[8B36FD28AE75]
n3:nazevZdroje
Neurobiology of Disease
n3:obor
n16:FH
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n8:2010
n3:svazekPeriodika
37
n3:tvurceVysledku
Chudomelová, Lenka
n3:wos
000274914100013
s:issn
0969-9961
s:numberOfPages
9
n5:organizacniJednotka
11120