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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F10%3A00002443%21RIV11-MZ0-11120___
rdf:type
skos:Concept n18:Vysledek
dcterms:description
The aim of the present study was to evaluate and compare the analgesic activity and serum levels of meloxicam (CAS 71125-38-7) after administration of meloxicam associated with beta-cyclodextrin (BCD, CAS 7585-39-9) and unmodified meloxicam. The analgesic activity was measured using the plantar test (rats) and the writhing test (mice). In the plantar test, BCD-meloxicam (3 mg/kg and 10 mg/kg orally) showed higher analgesic activity than corresponding doses of meloxicam alone; in the writhing test BCD-meloxicam (7 mg/kg and 15 mg/kg orally) showed stronger analgesic activity than unmodified meloxicam. Serum levels of meloxicam were significantly higher, at 0.5 h and 1 h after administration of BCD-meloxicam orally than those of unmodified meloxicam (both dosed at 10 mg/kg). The present results suggest that association with beta-cyclodextrin increases the analgesic activity of meloxicam. This may be due to an increased systemic bioavailability of meloxicam after oral administration of its complex with b The aim of the present study was to evaluate and compare the analgesic activity and serum levels of meloxicam (CAS 71125-38-7) after administration of meloxicam associated with beta-cyclodextrin (BCD, CAS 7585-39-9) and unmodified meloxicam. The analgesic activity was measured using the plantar test (rats) and the writhing test (mice). In the plantar test, BCD-meloxicam (3 mg/kg and 10 mg/kg orally) showed higher analgesic activity than corresponding doses of meloxicam alone; in the writhing test BCD-meloxicam (7 mg/kg and 15 mg/kg orally) showed stronger analgesic activity than unmodified meloxicam. Serum levels of meloxicam were significantly higher, at 0.5 h and 1 h after administration of BCD-meloxicam orally than those of unmodified meloxicam (both dosed at 10 mg/kg). The present results suggest that association with beta-cyclodextrin increases the analgesic activity of meloxicam. This may be due to an increased systemic bioavailability of meloxicam after oral administration of its complex with b
dcterms:title
Influence on analgesic activity and serum levels after meloxicam complexation with beta-cyclodextrin in mice and rats Influence on analgesic activity and serum levels after meloxicam complexation with beta-cyclodextrin in mice and rats
skos:prefLabel
Influence on analgesic activity and serum levels after meloxicam complexation with beta-cyclodextrin in mice and rats Influence on analgesic activity and serum levels after meloxicam complexation with beta-cyclodextrin in mice and rats
skos:notation
RIV/00216208:11120/10:00002443!RIV11-MZ0-11120___
n3:aktivita
n10:S n10:P n10:Z
n3:aktivity
P(NR9072), S, Z(MSM0021620816)
n3:cisloPeriodika
6
n3:dodaniDat
n12:2011
n3:domaciTvurceVysledku
n4:6758126 n4:3989925 n4:8183732 n4:1789511 n4:7541465
n3:druhVysledku
n6:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
263889
n3:idVysledku
RIV/00216208:11120/10:00002443
n3:jazykVysledku
n14:eng
n3:klicovaSlova
Beta-cyclodextrin; CAS 7585-39-9; CAS 71125-38-7; Meloxicam, analgesic activity; serum levels
n3:klicoveSlovo
n7:analgesic%20activity n7:serum%20levels n7:Beta-cyclodextrin n7:Meloxicam n7:CAS%2071125-38-7 n7:CAS%207585-39-9
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[007A3C8DEA20]
n3:nazevZdroje
Arzneimittel-Forschung-Drug Research
n3:obor
n11:FR
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n8:NR9072
n3:rokUplatneniVysledku
n12:2010
n3:svazekPeriodika
60
n3:tvurceVysledku
Doležal, Tomáš Slíva, Jiří Kršiak, Miloslav Janovský, Martin Procházková, Michaela
n3:wos
000279453700006
n3:zamer
n13:MSM0021620816
s:issn
0004-4172
s:numberOfPages
4
n16:organizacniJednotka
11120