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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F10%3A00002412%21RIV11-GA0-11120___
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Even though it is obvious that glutamate plays an important role in the effect of psychostimulants on seizures, the role of non-NMDA receptors remains uncertain. The aim of the present study was to determine whether acute methamphetamine (MA) administration changes sensitivity to seizures induced with kainic acid in prenatally MA-exposed adult rats. Adult male and female rats (prenatally MA exposed, prenatally saline exposed, and controls) were divided into groups that received a challenge dose (1 mg/kg) of MA and groups that did not receive the MA challenge (saline injected). Systemic administration of 15 mg/kg kainic acid was used as a seizure model. Our results demonstrated that a single injection of MA (1 mg/kg) affects kainic acid-induced seizures differently depending on prenatal exposure, sex, and female estrous cycle. Even though daily injections of MA (5 mg/kg) in maternal rats did not have a long-term effect on susceptibility to seizures induced with kainic acid in adult progeny, sensitivity Even though it is obvious that glutamate plays an important role in the effect of psychostimulants on seizures, the role of non-NMDA receptors remains uncertain. The aim of the present study was to determine whether acute methamphetamine (MA) administration changes sensitivity to seizures induced with kainic acid in prenatally MA-exposed adult rats. Adult male and female rats (prenatally MA exposed, prenatally saline exposed, and controls) were divided into groups that received a challenge dose (1 mg/kg) of MA and groups that did not receive the MA challenge (saline injected). Systemic administration of 15 mg/kg kainic acid was used as a seizure model. Our results demonstrated that a single injection of MA (1 mg/kg) affects kainic acid-induced seizures differently depending on prenatal exposure, sex, and female estrous cycle. Even though daily injections of MA (5 mg/kg) in maternal rats did not have a long-term effect on susceptibility to seizures induced with kainic acid in adult progeny, sensitivity
dcterms:title
Challenge dose of methamphetamine affects kainic acid-induced seizures differently depending on prenatal methamphetamine exposure, sex, and estrous cycle Challenge dose of methamphetamine affects kainic acid-induced seizures differently depending on prenatal methamphetamine exposure, sex, and estrous cycle
skos:prefLabel
Challenge dose of methamphetamine affects kainic acid-induced seizures differently depending on prenatal methamphetamine exposure, sex, and estrous cycle Challenge dose of methamphetamine affects kainic acid-induced seizures differently depending on prenatal methamphetamine exposure, sex, and estrous cycle
skos:notation
RIV/00216208:11120/10:00002412!RIV11-GA0-11120___
n3:aktivita
n4:P n4:Z
n3:aktivity
P(1M0517), P(GAP303/10/0580), Z(MSM0021620816)
n3:cisloPeriodika
1
n3:dodaniDat
n17:2011
n3:domaciTvurceVysledku
n7:6877141 n7:2722836 n7:3935981 n7:4939786 n7:1027980
n3:druhVysledku
n19:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
250252
n3:idVysledku
RIV/00216208:11120/10:00002412
n3:jazykVysledku
n9:eng
n3:klicovaSlova
Estrous cycle; Kainic acid; Methamphetamine; Seizures; Sex difference
n3:klicoveSlovo
n6:Seizures n6:Sex%20difference n6:Kainic%20acid n6:Methamphetamine n6:Estrous%20cycle
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[054D8BC0E58C]
n3:nazevZdroje
Epilepsy & Behavior
n3:obor
n11:FH
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n10:GAP303%2F10%2F0580 n10:1M0517
n3:rokUplatneniVysledku
n17:2010
n3:svazekPeriodika
19
n3:tvurceVysledku
Šlamberová, Romana Bernášková, Klára Rokyta, Richard Matějovská, Iveta Schutová, Barbora
n3:wos
000282395800005
n3:zamer
n13:MSM0021620816
s:issn
1525-5050
s:numberOfPages
6
n14:organizacniJednotka
11120