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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F10%3A00002386%21RIV11-MSM-11120___
rdf:type
n3:Vysledek skos:Concept
dcterms:description
We report a syngeneic model of spontaneous metastatic B16-F10 mouse melanoma in C57/BL6 mice with a very high metastatic frequency that mimics clinical metastatic melanoma. The B16 melanoma cells were injected between the skin and cartilage on the dorsal side of the ear. The model generated lymphatic and visceral metastases in all of the tested animals. In mice with large primary tumors, tumor weight correlated with the tumor growth time and also with the number of metastases in lymph nodes and organs. The dorsal ear space between the skin and cartilage enables both lymphatic and hematogenous metastatic spread. The model should be useful to study the mechanism of melanoma metastasis and to develop therapy for this currently untreatable disease. We report a syngeneic model of spontaneous metastatic B16-F10 mouse melanoma in C57/BL6 mice with a very high metastatic frequency that mimics clinical metastatic melanoma. The B16 melanoma cells were injected between the skin and cartilage on the dorsal side of the ear. The model generated lymphatic and visceral metastases in all of the tested animals. In mice with large primary tumors, tumor weight correlated with the tumor growth time and also with the number of metastases in lymph nodes and organs. The dorsal ear space between the skin and cartilage enables both lymphatic and hematogenous metastatic spread. The model should be useful to study the mechanism of melanoma metastasis and to develop therapy for this currently untreatable disease.
dcterms:title
A Clinically Relevant, Syngeneic Model of Spontaneous, Highly Metastatic B16 Mouse Melanoma A Clinically Relevant, Syngeneic Model of Spontaneous, Highly Metastatic B16 Mouse Melanoma
skos:prefLabel
A Clinically Relevant, Syngeneic Model of Spontaneous, Highly Metastatic B16 Mouse Melanoma A Clinically Relevant, Syngeneic Model of Spontaneous, Highly Metastatic B16 Mouse Melanoma
skos:notation
RIV/00216208:11120/10:00002386!RIV11-MSM-11120___
n4:aktivita
n14:P
n4:aktivity
P(KJB501070501), P(ME10045)
n4:cisloPeriodika
12
n4:dodaniDat
n10:2011
n4:domaciTvurceVysledku
n6:2394685 n6:8978182 n6:9313605 n6:6819362 n6:5704995
n4:druhVysledku
n11:J
n4:duvernostUdaju
n8:S
n4:entitaPredkladatele
n9:predkladatel
n4:idSjednocenehoVysledku
244495
n4:idVysledku
RIV/00216208:11120/10:00002386
n4:jazykVysledku
n16:eng
n4:klicovaSlova
Spontaneous metastasis; metastasis model; lymph node; B16 mouse melanoma
n4:klicoveSlovo
n13:metastasis%20model n13:lymph%20node n13:B16%20mouse%20melanoma n13:Spontaneous%20metastasis
n4:kodStatuVydavatele
GR - Řecká republika
n4:kontrolniKodProRIV
[5354E6F737C1]
n4:nazevZdroje
Anticancer Research
n4:obor
n17:FD
n4:pocetDomacichTvurcuVysledku
5
n4:pocetTvurcuVysledku
9
n4:projekt
n15:KJB501070501 n15:ME10045
n4:rokUplatneniVysledku
n10:2010
n4:svazekPeriodika
30
n4:tvurceVysledku
Kacprzak, Grzegorz Bobek, Vladimír Kubecová, Martina Kolodziej, Jerzy Adamiak, Jaroslaw Pintérová, Daniela Hoffman, Robert M. Kološtová, Katarína Boubelík, Michael
n4:wos
000287018100002
s:issn
0250-7005
s:numberOfPages
5
n18:organizacniJednotka
11120