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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F10%3A00001926%21RIV10-MZ0-11120___
rdf:type
skos:Concept n7:Vysledek
dcterms:description
The aim of our study was to examine the effect of prenatal methamphetamine (MA) exposure and cross-fostering on cognitive functions of adult male rats tested in Morris water maze (MWM). Rat mothers were exposed daily to injection of MA (5 mg/kg) or saline for 9 weeks: prior to impregnation, throughout gestation and lactation periods. Females without any injections were used as an absolute control. On postnatal day 1, pups were cross-fostered so that each mother raised 4 pups of her own and 8 pups from the mothers with the other two treatments. Four types of tests were used: (1) Place navigation test (Learning), (2) Probe test (Probe), (3) Retention memory test (Memory) and (4) Visible platform task. Our results demonstrate that the prenatal exposure to MA does not impact learning and memory, while postnatal exposure to MA shows impairments in cognition. In the test of learning, all animals fostered to MA-treated dams had longer latencies, bigger search error and used lower spatial strategies than the The aim of our study was to examine the effect of prenatal methamphetamine (MA) exposure and cross-fostering on cognitive functions of adult male rats tested in Morris water maze (MWM). Rat mothers were exposed daily to injection of MA (5 mg/kg) or saline for 9 weeks: prior to impregnation, throughout gestation and lactation periods. Females without any injections were used as an absolute control. On postnatal day 1, pups were cross-fostered so that each mother raised 4 pups of her own and 8 pups from the mothers with the other two treatments. Four types of tests were used: (1) Place navigation test (Learning), (2) Probe test (Probe), (3) Retention memory test (Memory) and (4) Visible platform task. Our results demonstrate that the prenatal exposure to MA does not impact learning and memory, while postnatal exposure to MA shows impairments in cognition. In the test of learning, all animals fostered to MA-treated dams had longer latencies, bigger search error and used lower spatial strategies than the
dcterms:title
Effect of methamphetamine exposure and cross-fostering on cognitive function in adult male rats Effect of methamphetamine exposure and cross-fostering on cognitive function in adult male rats
skos:prefLabel
Effect of methamphetamine exposure and cross-fostering on cognitive function in adult male rats Effect of methamphetamine exposure and cross-fostering on cognitive function in adult male rats
skos:notation
RIV/00216208:11120/10:00001926!RIV10-MZ0-11120___
n3:aktivita
n6:P n6:Z
n3:aktivity
P(1A8610), P(LC554), Z(MSM0021620816)
n3:cisloPeriodika
1
n3:dodaniDat
n17:2010
n3:domaciTvurceVysledku
n9:1128574 n9:6877141 n9:4939786 n9:1027980 n9:6841910
n3:druhVysledku
n19:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
256057
n3:idVysledku
RIV/00216208:11120/10:00001926
n3:jazykVysledku
n11:eng
n3:klicovaSlova
cognitive functions; cross-fostering; methamphetamine
n3:klicoveSlovo
n8:methamphetamine n8:cross-fostering n8:cognitive%20functions
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[5BC78ABEA5B8]
n3:nazevZdroje
Behavioural Brain Research
n3:obor
n14:ED
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n16:1A8610 n16:LC554
n3:rokUplatneniVysledku
n17:2010
n3:svazekPeriodika
208
n3:tvurceVysledku
Pometlová, Marie Schutová, Barbora Šlamberová, Romana Rokyta, Richard Hrubá, Lenka
n3:wos
000275625100008
n3:zamer
n18:MSM0021620816
s:issn
0166-4328
s:numberOfPages
9
n13:organizacniJednotka
11120