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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F09%3A00003815%21RIV12-MSM-11120___
rdf:type
n16:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1021/nl901603k
dcterms:description
To elucidate a mechanism of prothrombotic effects of carbon nanotubes (CNTs), we report here that multiwalled CNTs activate blood platelets by inducing extracellular Ca(2+) influx that could be inhibited by calcium channel blockers; SKF 96365 and 2-APB. We also demonstrate platelet aggregating activity of different single-walled and multiwalled CNTs. In addition, we show that CNT-induced platelet activation is associated with a marked release of platelet membrane microparticles positive for the granular secretion markers CD62P and CD63. To elucidate a mechanism of prothrombotic effects of carbon nanotubes (CNTs), we report here that multiwalled CNTs activate blood platelets by inducing extracellular Ca(2+) influx that could be inhibited by calcium channel blockers; SKF 96365 and 2-APB. We also demonstrate platelet aggregating activity of different single-walled and multiwalled CNTs. In addition, we show that CNT-induced platelet activation is associated with a marked release of platelet membrane microparticles positive for the granular secretion markers CD62P and CD63.
dcterms:title
Carbon Nanotubes Activate Blood Platelets by Inducing Extracellular Ca(2+) Influx Sensitive to Calcium Entry Inhibitors Carbon Nanotubes Activate Blood Platelets by Inducing Extracellular Ca(2+) Influx Sensitive to Calcium Entry Inhibitors
skos:prefLabel
Carbon Nanotubes Activate Blood Platelets by Inducing Extracellular Ca(2+) Influx Sensitive to Calcium Entry Inhibitors Carbon Nanotubes Activate Blood Platelets by Inducing Extracellular Ca(2+) Influx Sensitive to Calcium Entry Inhibitors
skos:notation
RIV/00216208:11120/09:00003815!RIV12-MSM-11120___
n3:aktivita
n12:Z n12:S n12:I
n3:aktivity
I, S, Z(MSM0021620806)
n3:cisloPeriodika
9
n3:dodaniDat
n10:2012
n3:domaciTvurceVysledku
n18:8387753
n3:druhVysledku
n17:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
305865
n3:idVysledku
RIV/00216208:11120/09:00003815
n3:jazykVysledku
n19:eng
n3:klicovaSlova
Cell-Membrane Microparticles; Toxicity; Nanoparticles; Nanomaterials; Aggregation; Mechanism; Penetration; Particles; Channels; Release
n3:klicoveSlovo
n5:Penetration n5:Cell-Membrane%20Microparticles n5:Aggregation n5:Particles n5:Toxicity n5:Channels n5:Nanoparticles n5:Release n5:Nanomaterials n5:Mechanism
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[A29A5FBFED13]
n3:nazevZdroje
Nano Letters
n3:obor
n15:CF
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n10:2009
n3:svazekPeriodika
9
n3:tvurceVysledku
Šemberová, Jana Simak, Jan
n3:wos
000269654900039
n3:zamer
n11:MSM0021620806
s:issn
1530-6984
s:numberOfPages
6
n20:doi
10.1021/nl901603k
n9:organizacniJednotka
11120