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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F09%3A00000494%21RIV09-GA0-11120___
rdf:type
skos:Concept n18:Vysledek
dcterms:description
Byl nalezen nový lidský lokus kontrolující IgE v poloze 8q12, homologní k myšímu Lmr9, jenž vykazuje nápadné spojení se senzibilizací na inhalované alergeny. (LOD=2,21-2,42). Dále byly identifikovány další lokusy na 5., 7., 12. a 13. chromozomu vázané na inhalační alergii. Nález spojení na 8q12 ukazuje na prediktivní sílu myších modelů pro průzkum komplexního znaku u člověka. Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against common environmental allergens. It is often associated with development of allergic diseases such as asthma, rhinitis, and dermatitis. Production of IgE is influenced by genetic and environmental factors. In spite of progress in the study of heredity of atopy, the genetic mechanisms of IgE regulation have not yet been completely elucidated. The analysis of complex traits can benefit considerably from integration of human and mouse genetics. Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against common environmental allergens. It is often associated with development of allergic diseases such as asthma, rhinitis, and dermatitis. Production of IgE is influenced by genetic and environmental factors. In spite of progress in the study of heredity of atopy, the genetic mechanisms of IgE regulation have not yet been completely elucidated. The analysis of complex traits can benefit considerably from integration of human and mouse genetics.
dcterms:title
Mouse to human comparative genetics reveals a novel immunoglobulin E-controlling locus on Hsa8q12 Srovnávací genetika myši a člověka odhaluje nový lokus na Hsa8q12 kontrolující IgE Mouse to human comparative genetics reveals a novel immunoglobulin E-controlling locus on Hsa8q12
skos:prefLabel
Mouse to human comparative genetics reveals a novel immunoglobulin E-controlling locus on Hsa8q12 Srovnávací genetika myši a člověka odhaluje nový lokus na Hsa8q12 kontrolující IgE Mouse to human comparative genetics reveals a novel immunoglobulin E-controlling locus on Hsa8q12
skos:notation
RIV/00216208:11120/09:00000494!RIV09-GA0-11120___
n3:aktivita
n10:P n10:Z
n3:aktivity
P(GA310/06/1745), P(LC06009), Z(AV0Z50520514), Z(MSM0021620812)
n3:cisloPeriodika
1
n3:dodaniDat
n4:2009
n3:domaciTvurceVysledku
n6:6111122 n6:9360344
n3:druhVysledku
n11:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
327555
n3:idVysledku
RIV/00216208:11120/09:00000494
n3:jazykVysledku
n9:eng
n3:klicovaSlova
Atopy; Specific IgE; Genetic loci; Mouse-human homology; Czech population; 8q12
n3:klicoveSlovo
n7:Atopy n7:Genetic%20loci n7:8q12 n7:Mouse-human%20homology n7:Czech%20population n7:Specific%20IgE
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[854AFE1872EC]
n3:nazevZdroje
Immunogenetics
n3:obor
n19:EC
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
9
n3:projekt
n16:LC06009 n16:GA310%2F06%2F1745
n3:rokUplatneniVysledku
n4:2009
n3:svazekPeriodika
61
n3:tvurceVysledku
Gusareva, E. S. Lipoldová, Marie Kučera, Petr
n3:wos
000263060800002
n3:zamer
n13:MSM0021620812 n13:AV0Z50520514
s:issn
0093-7711
s:numberOfPages
11
n14:organizacniJednotka
11120