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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F09%3A00000488%21RIV09-MSM-11120___
rdf:type
n4:Vysledek skos:Concept
dcterms:description
The aim of this study was to compare the expression of proteins potentially involved in non-transferrin iron transport across membranes (DMT1, Dcytb, ferroportin, hephaestin, and ceruloplasmin) in various types of human cells (Caco-2, K562 and HEP-G2) under extracellular iron deficiency and excess of extracellular non-transferrin iron. We demonstrated that changes in iron availability, i.e. iron deficiency and iron excess, affect the expression of DMT1, Dcytb, ferroportin, hephaestin and ceruloplasmin on mRNA as well as on protein level in a cell type-specific manner. The aim of this study was to compare the expression of proteins potentially involved in non-transferrin iron transport across membranes (DMT1, Dcytb, ferroportin, hephaestin, and ceruloplasmin) in various types of human cells (Caco-2, K562 and HEP-G2) under extracellular iron deficiency and excess of extracellular non-transferrin iron. We demonstrated that changes in iron availability, i.e. iron deficiency and iron excess, affect the expression of DMT1, Dcytb, ferroportin, hephaestin and ceruloplasmin on mRNA as well as on protein level in a cell type-specific manner. Cílem práce bylo porovnat expresi proteinů účastnících se transportu netransferinového železa přes membrány (DMT1, Dcytb, ferroportin, hephaestin, a ceruloplasmin) u různých typů lidských buněk (Caco-2, K562 and HEP-G2) pod vlivem deprivace a nadbytku extracelulárního netransferinového železa. Ukázali jsme, že změny v dostupnosti železa, tj. deprivace železa a nadbytek železa, ovlivňují expresi DMT1, Dcytb, ferroportinu, hephaestinu a ceruloplasminu na úrovni mRNA i proteinů v závislosti na daném typu buněk.
dcterms:title
Rozdílná exprese genů zúčastněných v transportu netransferinového železa přes plazmatickou membránu u různých typů buněk pod vlivem deprivace a nadbytku železa Differing expression of genes involved in non-transferrin iron transport across plasma membrane in various cell types under iron deficiency and excess Differing expression of genes involved in non-transferrin iron transport across plasma membrane in various cell types under iron deficiency and excess
skos:prefLabel
Differing expression of genes involved in non-transferrin iron transport across plasma membrane in various cell types under iron deficiency and excess Differing expression of genes involved in non-transferrin iron transport across plasma membrane in various cell types under iron deficiency and excess Rozdílná exprese genů zúčastněných v transportu netransferinového železa přes plazmatickou membránu u různých typů buněk pod vlivem deprivace a nadbytku železa
skos:notation
RIV/00216208:11120/09:00000488!RIV09-MSM-11120___
n3:aktivita
n17:Z
n3:aktivity
Z(MSM0021620814)
n3:cisloPeriodika
1-2
n3:dodaniDat
n8:2009
n3:domaciTvurceVysledku
n15:7090277 n15:1758330 n15:3566447 n15:1116339 n15:1217941
n3:druhVysledku
n14:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
310513
n3:idVysledku
RIV/00216208:11120/09:00000488
n3:jazykVysledku
n12:eng
n3:klicovaSlova
Non-transferrin iron transport; DMT1; Dcytb; Ferroportin; Hephaestin; Ceruloplasmin
n3:klicoveSlovo
n9:Hephaestin n9:DMT1 n9:Dcytb n9:Ferroportin n9:Ceruloplasmin n9:Non-transferrin%20iron%20transport
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[CC09B13863D2]
n3:nazevZdroje
Molecular and Cellular Biochemistry
n3:obor
n5:EB
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n8:2009
n3:svazekPeriodika
321
n3:tvurceVysledku
Dostalíková-Čimburová, Markéta Horák, Jiří Neubauerová, Jitka Kovář, Jan Balušíková, Kamila
n3:wos
000262402500013
n3:zamer
n10:MSM0021620814
s:issn
0300-8177
s:numberOfPages
11
n16:organizacniJednotka
11120