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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F08%3A00003125%21RIV12-MZ0-11120___
rdf:type
n8:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1016/j.schres.2008.04.013
dcterms:description
Cadherins and protocadherins are cell adhesion proteins that play an important role in neuronal migration, differentiation and synaptogenesis, properties that make them targets to consider in schizophrenia (SZ) and bipolar disorder (BD) pathogenesis. Consequently, allelic variation occurring in protocadherin and cadherin encoding genes that map to regions of the genome targeted in SZ and BD linkage studies are particularly strong candidates to consider. One such set of candidate genes is the 5q31-linked PCDH family, which consists of more than 50 exons encoding three related, though distinct family members - alpha, beta, and gamma - which can generate thousands of different protocadherin proteins through alternative promoter usage and cis-alternative splicing. In this study, we focused on a SNP, rs31745, which is located in a putative PCDH alpha enhancer mapped by ChIP-chip using antibodies to covalently modified histone H3. Cadherins and protocadherins are cell adhesion proteins that play an important role in neuronal migration, differentiation and synaptogenesis, properties that make them targets to consider in schizophrenia (SZ) and bipolar disorder (BD) pathogenesis. Consequently, allelic variation occurring in protocadherin and cadherin encoding genes that map to regions of the genome targeted in SZ and BD linkage studies are particularly strong candidates to consider. One such set of candidate genes is the 5q31-linked PCDH family, which consists of more than 50 exons encoding three related, though distinct family members - alpha, beta, and gamma - which can generate thousands of different protocadherin proteins through alternative promoter usage and cis-alternative splicing. In this study, we focused on a SNP, rs31745, which is located in a putative PCDH alpha enhancer mapped by ChIP-chip using antibodies to covalently modified histone H3.
dcterms:title
Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia
skos:prefLabel
Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia
skos:notation
RIV/00216208:11120/08:00003125!RIV12-MZ0-11120___
n3:aktivita
n16:P
n3:aktivity
P(NR8564)
n3:cisloPeriodika
1-3
n3:dodaniDat
n7:2012
n3:domaciTvurceVysledku
n18:8663807 n18:7625952
n3:druhVysledku
n17:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
355871
n3:idVysledku
RIV/00216208:11120/08:00003125
n3:jazykVysledku
n4:eng
n3:klicovaSlova
protocadherin; cadherin schizophrenia; bipolar disorder; chromatin
n3:klicoveSlovo
n5:cadherin%20schizophrenia n5:protocadherin n5:bipolar%20disorder n5:chromatin
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[8D17AC238535]
n3:nazevZdroje
Schizophrenia Research
n3:obor
n14:FL
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
9
n3:projekt
n19:NR8564
n3:rokUplatneniVysledku
n7:2008
n3:svazekPeriodika
102
n3:tvurceVysledku
Novák, Tomáš Stopková, Pavla
n3:wos
000257837700024
s:issn
0920-9964
s:numberOfPages
10
n11:doi
10.1016/j.schres.2008.04.013
n20:organizacniJednotka
11120