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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F08%3A00000994%21RIV09-MSM-11120___
rdf:type
skos:Concept n12:Vysledek
dcterms:description
Atopie je predispozice k hyperprodukci IgE proti okolním alergenům. Vývoj nemoci je ovlivněn vlivy genetickými a prostředím. Analyzovali jsme specifitu a intenzitu senzibilizace proti alergenům u atopických pacientů v České republice a na Ukrajině. Byly nalezeny významné rozdíly, nejvýznamnější alergeny na Ukrajině byly z roztočů a z koček, v ČR byla vyšší senzibilizace proti pylovým alergenům. Tento nález může odrážet vliv západního životního stylu na populaci. Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against common environmental allergens.. The development of these diseases is influenced by both genetic and environmental factors. As the first step in study of such gene-environment interactions we analyzed the specificity and intensity of sensitization to 40 different allergens in atopic patients from the Czech Republic and Ukradne. We found highly significant differences in sensitization to airborne allergens between patients from the two countries. The most pronounced allergens from Ukradne were dust mites allergens and cat. In the atopic patients from the Czech Republic the level of sensitization to these allergens was similar, but the level of sensitization to outdoor allergens, grasses and trees was dramatically higher. The higher sensitization levels to outdoor allergens in the Czech Republic suggest an influence of westernization on development of allergic reactivity. Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against common environmental allergens.. The development of these diseases is influenced by both genetic and environmental factors. As the first step in study of such gene-environment interactions we analyzed the specificity and intensity of sensitization to 40 different allergens in atopic patients from the Czech Republic and Ukradne. We found highly significant differences in sensitization to airborne allergens between patients from the two countries. The most pronounced allergens from Ukradne were dust mites allergens and cat. In the atopic patients from the Czech Republic the level of sensitization to these allergens was similar, but the level of sensitization to outdoor allergens, grasses and trees was dramatically higher. The higher sensitization levels to outdoor allergens in the Czech Republic suggest an influence of westernization on development of allergic reactivity.
dcterms:title
Odlišné vlivy prostředí na etiologii atopických chorob v evropských populacích jako základ studia interakce genů a okolního prostředí Different Environmental Influences on Aetiology of Atopic Diseases in European Populations as a Basis for Study of Gene-Environment Interactions Different Environmental Influences on Aetiology of Atopic Diseases in European Populations as a Basis for Study of Gene-Environment Interactions
skos:prefLabel
Different Environmental Influences on Aetiology of Atopic Diseases in European Populations as a Basis for Study of Gene-Environment Interactions Different Environmental Influences on Aetiology of Atopic Diseases in European Populations as a Basis for Study of Gene-Environment Interactions Odlišné vlivy prostředí na etiologii atopických chorob v evropských populacích jako základ studia interakce genů a okolního prostředí
skos:notation
RIV/00216208:11120/08:00000994!RIV09-MSM-11120___
n5:aktivita
n17:Z
n5:aktivity
Z(MSM0021620812)
n5:dodaniDat
n9:2009
n5:domaciTvurceVysledku
n11:6111122 n11:9360344
n5:druhVysledku
n13:C
n5:duvernostUdaju
n20:S
n5:entitaPredkladatele
n14:predkladatel
n5:idSjednocenehoVysledku
363548
n5:idVysledku
RIV/00216208:11120/08:00000994
n5:jazykVysledku
n15:eng
n5:klicovaSlova
Atopy; sensitization; IgE; mites and pollen allergens
n5:klicoveSlovo
n6:Atopy n6:IgE n6:mites%20and%20pollen%20allergens n6:sensitization
n5:kontrolniKodProRIV
[A291758126E3]
n5:mistoVydani
New York
n5:nazevZdroje
Genetic Predisposition to Disease
n5:obor
n18:EB
n5:pocetDomacichTvurcuVysledku
2
n5:pocetStranKnihy
278
n5:pocetTvurcuVysledku
8
n5:rokUplatneniVysledku
n9:2008
n5:tvurceVysledku
Savvo, A. Lipoldová, Marie Belozorova, A. P. Král, V. Blažková, H. Kučera, Petr Gusareva, E. S. Havelková, H.
n5:zamer
n19:MSM0021620812
s:numberOfPages
14
n8:hasPublisher
Nova Science Publishers
n4:isbn
978-1-60456-835-6
n16:organizacniJednotka
11120