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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F08%3A00000710%21RIV09-MSM-11120___
rdf:type
skos:Concept n8:Vysledek
dcterms:description
BACKGROUND AND OBJECTIVE: Vestibular dysfunction commonly leads to - often severe - vertigo symptoms. The objective of this study was to compare the antivertiginous efficacy and tolerability of a fixed combination of cinnarizine/dimenhydrinate with those of betahistine in patients with acute vertigo due to vestibular disorders. METHODS: Sixty-six patients experiencing acute vertigo attacks participated in this prospective, double-blind, three-centre, comparative study. Patients who assessed at least one vertigo symptom as being of medium intensity (> or =2) on a 5-point visual analogue scale (VAS; from 0 = no symptoms to 4 = very severe symptoms) were randomly allocated to treatment with the fixed combination of cinnarizine 20 mg and dimenhydrinate 40 mg three times daily or betahistine 12 mg three times daily for 4 weeks. The primary efficacy endpoint was change in mean vertigo score, as determined by patients' assessments of 12 individual vertigo symptoms on the 5-point VAS after 4 weeks of BACKGROUND AND OBJECTIVE: Vestibular dysfunction commonly leads to - often severe - vertigo symptoms. The objective of this study was to compare the antivertiginous efficacy and tolerability of a fixed combination of cinnarizine/dimenhydrinate with those of betahistine in patients with acute vertigo due to vestibular disorders. METHODS: Sixty-six patients experiencing acute vertigo attacks participated in this prospective, double-blind, three-centre, comparative study. Patients who assessed at least one vertigo symptom as being of medium intensity (> or =2) on a 5-point visual analogue scale (VAS; from 0 = no symptoms to 4 = very severe symptoms) were randomly allocated to treatment with the fixed combination of cinnarizine 20 mg and dimenhydrinate 40 mg three times daily or betahistine 12 mg three times daily for 4 weeks. The primary efficacy endpoint was change in mean vertigo score, as determined by patients' assessments of 12 individual vertigo symptoms on the 5-point VAS after 4 weeks of Předmětem studie bylo porovant antivertigogenní účinnost a toleranci pevné kombinace cinnarizin/dimenhydrinát s betahistidinem u pacientů s akutním vertigem způsobeným vestibulárním onemocněním
dcterms:title
A fixed combination of cinnarizine/dimenhydrinate for the treatment of patients with acute vertigo due to vestibular disorders : a randomized, reference-controlled clinical study Pevná kombinace cinnarizin/dimenhydrinát pro léčbu pacientů s akutním vertigem způsobeným vestibulárním onemocněním: randomizovaná, literaturo ověřená klinická studie A fixed combination of cinnarizine/dimenhydrinate for the treatment of patients with acute vertigo due to vestibular disorders : a randomized, reference-controlled clinical study
skos:prefLabel
Pevná kombinace cinnarizin/dimenhydrinát pro léčbu pacientů s akutním vertigem způsobeným vestibulárním onemocněním: randomizovaná, literaturo ověřená klinická studie A fixed combination of cinnarizine/dimenhydrinate for the treatment of patients with acute vertigo due to vestibular disorders : a randomized, reference-controlled clinical study A fixed combination of cinnarizine/dimenhydrinate for the treatment of patients with acute vertigo due to vestibular disorders : a randomized, reference-controlled clinical study
skos:notation
RIV/00216208:11120/08:00000710!RIV09-MSM-11120___
n3:aktivita
n17:S
n3:aktivity
S
n3:cisloPeriodika
2
n3:dodaniDat
n11:2009
n3:domaciTvurceVysledku
n14:8989907 n14:7003900
n3:druhVysledku
n6:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
354184
n3:idVysledku
RIV/00216208:11120/08:00000710
n3:jazykVysledku
n16:eng
n3:klicovaSlova
double-blind; healthy-volunteers; parallel-group; hair-cells; cinnarizine; dimenhydrinate; tolerability; efficacy; currents; calcium
n3:klicoveSlovo
n4:healthy-volunteers n4:currents n4:cinnarizine n4:tolerability n4:efficacy n4:dimenhydrinate n4:double-blind n4:parallel-group n4:hair-cells n4:calcium
n3:kodStatuVydavatele
NZ - Nový Zéland
n3:kontrolniKodProRIV
[560328BD5AD4]
n3:nazevZdroje
Clinical Drug Investigation
n3:obor
n10:FF
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n11:2008
n3:svazekPeriodika
28
n3:tvurceVysledku
Hahn, Aleš Schwarz, M. Štefflová, B. Baumann, W. Šejna, Ivan
n3:wos
000253244400003
s:issn
1173-2563
s:numberOfPages
11
n12:organizacniJednotka
11120