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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F08%3A00000555%21RIV09-GA0-11120___
rdf:type
n7:Vysledek skos:Concept
dcterms:description
Tato práce popisuje účinky nového alfa2-adrenergního agonisty naftylmedetomidinu u myší. Tato látka byla podávána v dávkách 150-1200 mikrog/kg i.p. u myší a její účinky sledovány pomocí aktivitní klece a testu sociálního konfliktu. Naftylmedetomidin velmi výrazně tlumil agresivitu v dávkách, které ještě nezpůsobovaly sedaci. Dalším zajímavých zjištěním bylo, že atipamezol, alfa2-adrenergní agonista, byl schopen pouze částečně antagonizovat účinky naftylmedetomidinu na sedaci. Takto vysoce selektivní antiagresivní účinek je pozorován velmi zřídka. Tato práce tak poukazuje na potenciální možnosti naftlymedetomidinu ve zvládání agresivních stavů. Alpha-2 adrenoceptors (alpha(2)-ARs) are critically involved in regulating neurotransmitter release from sympathetic nerves and neurons and play an important role in the regulation of awareness, arousal and vigilance. In our recent study, dexmedetomidine, a full alpha(2)-AR agonist, produced antiaggressive effects in the social conflict test in mice at doses that were twice smaller than those producing sedation. The aim of this study was to ascertain antiaggressive effect of a novel drug naphthylmedetomidine, with a more selective alpha(2)-AR activity. Behavioral effects of naphthylmedetomidine (150-1200 microg/kg i.p.) were studied in the activity cage and in the social conflict tests in mice. Naphthylmedetomidine dose dependently decreased aggressive behavior during social conflict in aggressive mice with significant reduction already at the lowest doses tested (150 microg/kg), whereas locomotion and social investigation were significantly decreased only after four times bigger dose of naphthylmedet Alpha-2 adrenoceptors (alpha(2)-ARs) are critically involved in regulating neurotransmitter release from sympathetic nerves and neurons and play an important role in the regulation of awareness, arousal and vigilance. In our recent study, dexmedetomidine, a full alpha(2)-AR agonist, produced antiaggressive effects in the social conflict test in mice at doses that were twice smaller than those producing sedation. The aim of this study was to ascertain antiaggressive effect of a novel drug naphthylmedetomidine, with a more selective alpha(2)-AR activity. Behavioral effects of naphthylmedetomidine (150-1200 microg/kg i.p.) were studied in the activity cage and in the social conflict tests in mice. Naphthylmedetomidine dose dependently decreased aggressive behavior during social conflict in aggressive mice with significant reduction already at the lowest doses tested (150 microg/kg), whereas locomotion and social investigation were significantly decreased only after four times bigger dose of naphthylmedet
dcterms:title
Selective antiaggressive effect of an alpha-2 adrenoceptor agonist naphthylmedetomidine in mice Selective antiaggressive effect of an alpha-2 adrenoceptor agonist naphthylmedetomidine in mice Selektivní antiagresivní účinek alfa2-adrenergního agonisty naftylmedetomidinu u myší
skos:prefLabel
Selective antiaggressive effect of an alpha-2 adrenoceptor agonist naphthylmedetomidine in mice Selective antiaggressive effect of an alpha-2 adrenoceptor agonist naphthylmedetomidine in mice Selektivní antiagresivní účinek alfa2-adrenergního agonisty naftylmedetomidinu u myší
skos:notation
RIV/00216208:11120/08:00000555!RIV09-GA0-11120___
n3:aktivita
n4:Z n4:P
n3:aktivity
P(GP305/05/P003), P(NR8508), Z(MSM0021620816)
n3:cisloPeriodika
4
n3:dodaniDat
n9:2009
n3:domaciTvurceVysledku
n18:6113141 n18:8183732
n3:druhVysledku
n13:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
394176
n3:idVysledku
RIV/00216208:11120/08:00000555
n3:jazykVysledku
n17:eng
n3:klicovaSlova
naphthylmedetomidine; atipamezole; animal behavior; aggression; alpha-2 adrenoceptor
n3:klicoveSlovo
n10:aggression n10:atipamezole n10:naphthylmedetomidine n10:alpha-2%20adrenoceptor n10:animal%20behavior
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[0C1AE0CB2ED0]
n3:nazevZdroje
Aggresive Behavior
n3:obor
n16:FR
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
3
n3:projekt
n6:GP305%2F05%2FP003 n6:NR8508
n3:rokUplatneniVysledku
n9:2008
n3:svazekPeriodika
34
n3:tvurceVysledku
Kršiak, Miloslav Hess, Ladislav Votava, Martin
n3:wos
000256645800005
n3:zamer
n15:MSM0021620816
s:issn
0096-140X
s:numberOfPages
10
n19:organizacniJednotka
11120