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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F08%3A00000539%21RIV09-MZ0-11120___
rdf:type
n16:Vysledek skos:Concept
dcterms:description
Novoobjaveny adipokin, visfatin, se dava do souvisu s obezitou u lidi a je regulovaný vicerými hormonálnimi signálmi. Cílem teto studie bylo sledovat vztah exprese visfatinu v tukové tkání s potenciálnimi regulačnými faktormi jako je inzulin, testosterone a TNFa a sledovat efekt diety na hladiny mRNA v tukové tkáni a plazmatické hladiny visfatinu. Background: A novel adipokine, visfatin, was found to be related to adiposity in humans and regulated by a number of hormonal signals. The aim of this study was to investigate the relationships of visfatin expression in adipose tissue with potential regulatory factors such as insulin, testosterone and tumor necrosis factor-alpha (TNF-alpha) and to elucidate the effect of a diet induced weight reduction on adipose tissue mRNA expression and plasma levels of visfatin. MATERIALS AND METHODS: Biopsies of subcutaneous abdominal adipose tissue (SCAAT) and plasma samples were obtained at the beginning of the study from 47 pre-menopausal women (age 38.7 +/- 1.7 years, body mass index (BMI) 27.9 +/- 1.4 kg m(-2)), consisting of 15 lean, 16 overweight and 16 obese subjects. The subgroup of 32 overweight/obese women (age 42.1 +/- 1.9 years, BMI 31.2 +/- 0.9 kg m(-2)) underwent a 12 week hypocaloric weight reducing diet and samples were obtained at the end of the diet. Biopsy samples were analysed for visfatin an Background: A novel adipokine, visfatin, was found to be related to adiposity in humans and regulated by a number of hormonal signals. The aim of this study was to investigate the relationships of visfatin expression in adipose tissue with potential regulatory factors such as insulin, testosterone and tumor necrosis factor-alpha (TNF-alpha) and to elucidate the effect of a diet induced weight reduction on adipose tissue mRNA expression and plasma levels of visfatin. MATERIALS AND METHODS: Biopsies of subcutaneous abdominal adipose tissue (SCAAT) and plasma samples were obtained at the beginning of the study from 47 pre-menopausal women (age 38.7 +/- 1.7 years, body mass index (BMI) 27.9 +/- 1.4 kg m(-2)), consisting of 15 lean, 16 overweight and 16 obese subjects. The subgroup of 32 overweight/obese women (age 42.1 +/- 1.9 years, BMI 31.2 +/- 0.9 kg m(-2)) underwent a 12 week hypocaloric weight reducing diet and samples were obtained at the end of the diet. Biopsy samples were analysed for visfatin an
dcterms:title
Visfatin expression in subcutaneous adipose tissue of pre-menopausal women: relation to hormones and weight reduction Visfatin expression in subcutaneous adipose tissue of pre-menopausal women: relation to hormones and weight reduction Exprese visfatinu v podkožní tukové tkáni u premenopausálích žen: vztah k hladinám hormonů a redukce váhy
skos:prefLabel
Visfatin expression in subcutaneous adipose tissue of pre-menopausal women: relation to hormones and weight reduction Visfatin expression in subcutaneous adipose tissue of pre-menopausal women: relation to hormones and weight reduction Exprese visfatinu v podkožní tukové tkáni u premenopausálích žen: vztah k hladinám hormonů a redukce váhy
skos:notation
RIV/00216208:11120/08:00000539!RIV09-MZ0-11120___
n3:aktivita
n7:Z n7:P
n3:aktivity
P(NR9161), Z(MSM0021620814)
n3:cisloPeriodika
7
n3:dodaniDat
n10:2009
n3:domaciTvurceVysledku
n8:9021000 n8:8393249 n8:6702554 n8:7508808 n8:2450569 n8:4377974 n8:2809508 n8:3966577
n3:druhVysledku
n12:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
402791
n3:idVysledku
RIV/00216208:11120/08:00000539
n3:jazykVysledku
n14:eng
n3:klicovaSlova
Adipose tissue; mRNA expression; obesity; TNF-α; visfatin; weight reduction
n3:klicoveSlovo
n6:visfatin n6:mRNA%20expression n6:weight%20reduction n6:obesity n6:Adipose%20tissue n6:TNF-%CE%B1
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[59624BEED984]
n3:nazevZdroje
European Journal of Clinical Investigation
n3:obor
n15:FB
n3:pocetDomacichTvurcuVysledku
8
n3:pocetTvurcuVysledku
10
n3:projekt
n13:NR9161
n3:rokUplatneniVysledku
n10:2008
n3:svazekPeriodika
38
n3:tvurceVysledku
Klimčáková, Eva Polák, Jan Hejnová, Jindřiška Viguerie, N. Kováčová, Zuzana Bajzová, Magda Vítková, Michaela Kováčiková, Michaela Štich, Vladimír Langin, D.
n3:wos
000256686000009
n3:zamer
n17:MSM0021620814
s:issn
0014-2972
s:numberOfPages
7
n19:organizacniJednotka
11120