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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F07%3A00002195%21RIV11-MSM-11120___
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Reactive metabolites of benzene 1,4-benzoquinone and 1,4-hydroquinone exert their toxic effects through covalent and/or oxidative damage to DNA and proteins. Since minipigs have been proposed as a suitable model species in toxicological and pharmacological research, the aim of this study was to explore mechanisms by which catechol, 1,4-hydroquinone and 1,4-benzoquinone destroy cytochrome P450 (P450) and induce oxidative stress in minipig liver microsomes. Our second goal was to assess the usefulness of minipig liver microsomes as a model system for the testing of the production of oxidative stress by clinically relevant quinone-containing compounds, e.g. anthracyclines. Of the three benzene metabolites tested, the highest P450 destruction was caused by 1,4-benzoquinone. This destructive effect did not correlate with the production of hydroxyl radicals as measured by ESR spin trapping which was the highest in samples containing 1,4-hydroquinone. Our results confirm previous findings that 1,4-benzoquino Reactive metabolites of benzene 1,4-benzoquinone and 1,4-hydroquinone exert their toxic effects through covalent and/or oxidative damage to DNA and proteins. Since minipigs have been proposed as a suitable model species in toxicological and pharmacological research, the aim of this study was to explore mechanisms by which catechol, 1,4-hydroquinone and 1,4-benzoquinone destroy cytochrome P450 (P450) and induce oxidative stress in minipig liver microsomes. Our second goal was to assess the usefulness of minipig liver microsomes as a model system for the testing of the production of oxidative stress by clinically relevant quinone-containing compounds, e.g. anthracyclines. Of the three benzene metabolites tested, the highest P450 destruction was caused by 1,4-benzoquinone. This destructive effect did not correlate with the production of hydroxyl radicals as measured by ESR spin trapping which was the highest in samples containing 1,4-hydroquinone. Our results confirm previous findings that 1,4-benzoquino
dcterms:title
Cytochrome P450 destruction by benzene metabolites 1,4-benzoquinone and 1,4-hydroquinone and the formation of hydroxyl radicals in minipig liver microsomes Cytochrome P450 destruction by benzene metabolites 1,4-benzoquinone and 1,4-hydroquinone and the formation of hydroxyl radicals in minipig liver microsomes
skos:prefLabel
Cytochrome P450 destruction by benzene metabolites 1,4-benzoquinone and 1,4-hydroquinone and the formation of hydroxyl radicals in minipig liver microsomes Cytochrome P450 destruction by benzene metabolites 1,4-benzoquinone and 1,4-hydroquinone and the formation of hydroxyl radicals in minipig liver microsomes
skos:notation
RIV/00216208:11120/07:00002195!RIV11-MSM-11120___
n3:aktivita
n12:S n12:P n12:Z
n3:aktivity
P(NL7567), P(OC 119), S, Z(AV0Z40320502)
n3:cisloPeriodika
4
n3:dodaniDat
n19:2011
n3:domaciTvurceVysledku
n14:8679827 n14:1577999
n3:druhVysledku
n13:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
415531
n3:idVysledku
RIV/00216208:11120/07:00002195
n3:jazykVysledku
n8:eng
n3:klicovaSlova
cytochrome P450; hydroquinone; benzoquinone; P450; destruction; hydroxyl radicals; ESR
n3:klicoveSlovo
n4:hydroquinone n4:destruction n4:P450 n4:cytochrome%20P450 n4:benzoquinone n4:ESR n4:hydroxyl%20radicals
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[865DD641F037]
n3:nazevZdroje
Toxicology in Vitro
n3:obor
n5:DN
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
3
n3:projekt
n6:NL7567 n6:OC%20119
n3:rokUplatneniVysledku
n19:2007
n3:svazekPeriodika
21
n3:tvurceVysledku
Souček, Pavel Stopka, Pavel Kondrová, Eliška
n3:wos
000247131600004
n3:zamer
n15:AV0Z40320502
s:issn
0887-2333
s:numberOfPages
10
n16:organizacniJednotka
11120