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Statements

Subject Item

n2:RIV%2F00216208%3A11120%2F07%3A00001013%21RIV09-MSM-11120___

rdf:type

skos:Concept n16:Vysledek

dcterms:description

Menièrova choroba je idiopatické nitroušní onemocnění charakterizované kolísavou ztrátou sluchu, občasným vertigem a tinnitem Ménière's disease (MD) is an idiopathic inner-ear disorder characterized by fluctuating hearing loss, episodic vertigo, and tinnitus. Though MD's etiology is unknown, growing evidence suggests that autoimmunity may be involved in its development. The aim of this prospective study was to investigate the presence of anti-heat shock protein 70 (anti-HSP70) antibodies during the acute phase of MD and to relate its presence to the antibody pattern. We examined the sera of 13 patients by Western blot immunoassays for reactivity to bovine inner-ear antigen (anti-HSP70) antibodies. The presence of viral antibodies and autoantibodies (herpes simplex, types 1, 2; herpes zoster; cytomegalovirus; Epstein-Barr; IgM; IgG; cardiolipin; thyroglobulin and thyroperoxidase; and antinuclear, antimitochondrial, and anti-smooth-cell antibodies) were also tested. We found reactivity to HSP70 in only 1 of the 13 MD patients (7.7%), and it occurred during herpes zoster reactivation. We found no relationship bet Ménière's disease (MD) is an idiopathic inner-ear disorder characterized by fluctuating hearing loss, episodic vertigo, and tinnitus. Though MD's etiology is unknown, growing evidence suggests that autoimmunity may be involved in its development. The aim of this prospective study was to investigate the presence of anti-heat shock protein 70 (anti-HSP70) antibodies during the acute phase of MD and to relate its presence to the antibody pattern. We examined the sera of 13 patients by Western blot immunoassays for reactivity to bovine inner-ear antigen (anti-HSP70) antibodies. The presence of viral antibodies and autoantibodies (herpes simplex, types 1, 2; herpes zoster; cytomegalovirus; Epstein-Barr; IgM; IgG; cardiolipin; thyroglobulin and thyroperoxidase; and antinuclear, antimitochondrial, and anti-smooth-cell antibodies) were also tested. We found reactivity to HSP70 in only 1 of the 13 MD patients (7.7%), and it occurred during herpes zoster reactivation. We found no relationship bet

dcterms:title

Virová infekce a sérové protilátky proti 'heat shock protein 70' v akutní fázi Meniérovy choroby Viral infection and serum antibodies to heat shock protein 70 in the acute phase of Ménière's disease Viral infection and serum antibodies to heat shock protein 70 in the acute phase of Ménière's disease

skos:prefLabel

Virová infekce a sérové protilátky proti 'heat shock protein 70' v akutní fázi Meniérovy choroby Viral infection and serum antibodies to heat shock protein 70 in the acute phase of Ménière's disease Viral infection and serum antibodies to heat shock protein 70 in the acute phase of Ménière's disease

skos:notation

RIV/00216208:11120/07:00001013!RIV09-MSM-11120___

n3:aktivita

n15:S

n3:aktivity

S

n3:cisloPeriodika

2

n3:dodaniDat

n9:2009

n3:domaciTvurceVysledku

n12:8989907

n3:druhVysledku

n17:J

n3:duvernostUdaju

n10:S

n3:entitaPredkladatele

n11:predkladatel

n3:idSjednocenehoVysledku

457957

n3:idVysledku

RIV/00216208:11120/07:00001013

n3:jazykVysledku

n4:eng

n3:klicovaSlova

anti heat shock protein 70 antibodies; autoantibodies; cytomegalovirus; herpes-virus; Meniére's disease

n3:klicoveSlovo

n8:Meni%C3%A9re%27s%20disease n8:anti%20heat%20shock%20protein%2070%20antibodies n8:autoantibodies n8:cytomegalovirus n8:herpes-virus

n3:kodStatuVydavatele

US - Spojené státy americké

n3:kontrolniKodProRIV

[31C38B20A625]

n3:nazevZdroje

International Tinnitus Journal

n3:obor

n13:FF

n3:pocetDomacichTvurcuVysledku

1

n3:pocetTvurcuVysledku

4

n3:rokUplatneniVysledku

n9:2007

n3:svazekPeriodika

13

n3:tvurceVysledku

Hahn, Aleš Di Berardino, F. Cesarani, A. Alpini, D.

s:issn

0946-5448

s:numberOfPages

4

n14:organizacniJednotka

11120