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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F07%3A00000465%21RIV08-MSM-11120___
rdf:type
n11:Vysledek skos:Concept
dcterms:description
Rapid loss of adoptively transferred tumor-specific CD8(+) T cells (T-CD8) following Ag recognition in the periphery and their limited accumulation within the tumor stroma reduces the effectiveness of T cell-based immunotherapy. To better understand the role of T-CD8 in the control of autochthonous tumors, we have used mice of the RIP1-Tag4 lineage that develop pancreatic beta cell tumors due to expression of the SV40 large T Ag from the rat insulin promoter. We previously showed that the kinetics of functional T-CD8 tolerance varies toward two distinct epitopes derived from T Ag. Epitope I ((206)SAINNYAQKL(215))-specific T-CD8 are rapidly deleted whereas T-CD8 targeting epitope IV (404VVYDFLKC411) persist over the lifetime of tumor-bearing animals. In this report, we show that the conditioning of tumor-bearing RIP1-Tag4 mice with agonistic anti-CD40 Ab induces extensive expansion of naive epitope I-specific TCR transgenic (TCR-I) T cells in this tolerogenic environment and delays their loss from the Autoři uvádějí, že aplikace anti-CD40 protilátky zvyšuje imunitní odpověď na slabé nádorové antigeny Rapid loss of adoptively transferred tumor-specific CD8(+) T cells (T-CD8) following Ag recognition in the periphery and their limited accumulation within the tumor stroma reduces the effectiveness of T cell-based immunotherapy. To better understand the role of T-CD8 in the control of autochthonous tumors, we have used mice of the RIP1-Tag4 lineage that develop pancreatic beta cell tumors due to expression of the SV40 large T Ag from the rat insulin promoter. We previously showed that the kinetics of functional T-CD8 tolerance varies toward two distinct epitopes derived from T Ag. Epitope I ((206)SAINNYAQKL(215))-specific T-CD8 are rapidly deleted whereas T-CD8 targeting epitope IV (404VVYDFLKC411) persist over the lifetime of tumor-bearing animals. In this report, we show that the conditioning of tumor-bearing RIP1-Tag4 mice with agonistic anti-CD40 Ab induces extensive expansion of naive epitope I-specific TCR transgenic (TCR-I) T cells in this tolerogenic environment and delays their loss from the
dcterms:title
Aplikace anti-CD40 protilátky zvyšuje imunitní odpověď na slabé nádorové antigeny Anti-CD40 conditioning enhances the T(CD8) response to a highly tolerogenic epitope and subsequent immunotherapy of simian virus 40 T antigen-induced pancreatic tumors Anti-CD40 conditioning enhances the T(CD8) response to a highly tolerogenic epitope and subsequent immunotherapy of simian virus 40 T antigen-induced pancreatic tumors
skos:prefLabel
Aplikace anti-CD40 protilátky zvyšuje imunitní odpověď na slabé nádorové antigeny Anti-CD40 conditioning enhances the T(CD8) response to a highly tolerogenic epitope and subsequent immunotherapy of simian virus 40 T antigen-induced pancreatic tumors Anti-CD40 conditioning enhances the T(CD8) response to a highly tolerogenic epitope and subsequent immunotherapy of simian virus 40 T antigen-induced pancreatic tumors
skos:notation
RIV/00216208:11120/07:00000465!RIV08-MSM-11120___
n4:strany
6686-6695
n4:aktivita
n5:V
n4:aktivity
V
n4:cisloPeriodika
10
n4:dodaniDat
n17:2008
n4:domaciTvurceVysledku
n6:1402889
n4:druhVysledku
n15:J
n4:duvernostUdaju
n8:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
410126
n4:idVysledku
RIV/00216208:11120/07:00000465
n4:jazykVysledku
n13:eng
n4:klicovaSlova
in-vivo ligation; transgenic mice; cross-presentation; cell tolerance; cutting edge; lymphocyte responses; endothelial-cells; effector function; dendritic cells; immune-system
n4:klicoveSlovo
n7:in-vivo%20ligation n7:effector%20function n7:dendritic%20cells n7:endothelial-cells n7:cell%20tolerance n7:cutting%20edge n7:lymphocyte%20responses n7:cross-presentation n7:transgenic%20mice n7:immune-system
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[1D0AAB43B379]
n4:nazevZdroje
Journal of Immunology
n4:obor
n12:FN
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
4
n4:rokUplatneniVysledku
n17:2007
n4:svazekPeriodika
179
n4:tvurceVysledku
Knowles, B. Tevethia, S. Schell, T. Otáhal, Pavel
s:issn
0022-1767
s:numberOfPages
10
n14:organizacniJednotka
11120