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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F07%3A00000303%21RIV08-MSM-11120___
rdf:type
n11:Vysledek skos:Concept
dcterms:description
Osteoarthritis (OA) is a degenerative joint disease.Th ejoints are characterized by a progressive degeneration of articular cartilage leading to inflammattion and pain.In attempt to study the pathophysiology of OA, numerous experimental model that mimic human OA have been developed.Chemical models of OA involve intraarticular injection of chemical compounds that can have a number of effects on joint physiology.Surgical models of OA induce joint instability by partial menisectomy.One of the most frequently used model is the model of monoiodoacetate (MIA) induced OA.Local injection of monoiodoacetate, an inhibitor of glycolysis,disrupt chondrocyte metabolism and produces cartilage degeneration.In mice,injection of monoiodoacetate led to strong inhibition of proteoglycan synthesis in the patella and in the medial part of tibial plateau.The loss of locomotor activity and the severity of cartilage lesions in patella were observed in rats injected with MIA.It was previously described, the important role of Osteoarthritis (OA) is a degenerative joint disease.Th ejoints are characterized by a progressive degeneration of articular cartilage leading to inflammattion and pain.In attempt to study the pathophysiology of OA, numerous experimental model that mimic human OA have been developed.Chemical models of OA involve intraarticular injection of chemical compounds that can have a number of effects on joint physiology.Surgical models of OA induce joint instability by partial menisectomy.One of the most frequently used model is the model of monoiodoacetate (MIA) induced OA.Local injection of monoiodoacetate, an inhibitor of glycolysis,disrupt chondrocyte metabolism and produces cartilage degeneration.In mice,injection of monoiodoacetate led to strong inhibition of proteoglycan synthesis in the patella and in the medial part of tibial plateau.The loss of locomotor activity and the severity of cartilage lesions in patella were observed in rats injected with MIA.It was previously described, the important role of Práce popisuje problematiku exprese a produkce spinální cyklooxygenázy 1 a 2 v modelu experimentální osteoartritídy
dcterms:title
Expression and production of spinal cyclooxygenase 1 and 2 in the model of experimental osteoarthritis Exprese a produkce spinální cyklooxygenázy 1 a 2 v modelu experimentální osteoartritídy Expression and production of spinal cyclooxygenase 1 and 2 in the model of experimental osteoarthritis
skos:prefLabel
Expression and production of spinal cyclooxygenase 1 and 2 in the model of experimental osteoarthritis Exprese a produkce spinální cyklooxygenázy 1 a 2 v modelu experimentální osteoartritídy Expression and production of spinal cyclooxygenase 1 and 2 in the model of experimental osteoarthritis
skos:notation
RIV/00216208:11120/07:00000303!RIV08-MSM-11120___
n3:strany
73-74
n3:aktivita
n10:P n10:Z
n3:aktivity
P(NR9072), Z(MSM0021620816)
n3:cisloPeriodika
Suppl. 1
n3:dodaniDat
n17:2008
n3:domaciTvurceVysledku
n14:7541465 n14:3989925 n14:8183732
n3:druhVysledku
n15:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
421403
n3:idVysledku
RIV/00216208:11120/07:00000303
n3:jazykVysledku
n4:eng
n3:klicovaSlova
osteoarthritis; cyclooxygenase; spinal cord; pain
n3:klicoveSlovo
n12:cyclooxygenase n12:spinal%20cord n12:pain n12:osteoarthritis
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[B22EF0BB67D0]
n3:nazevZdroje
Biomedical Papers
n3:obor
n6:FR
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
5
n3:projekt
n9:NR9072
n3:rokUplatneniVysledku
n17:2007
n3:svazekPeriodika
151
n3:tvurceVysledku
Zanvit, P. Kršiak, Miloslav Prokešová, L. Procházková, Michaela Doležal, Tomáš
n3:zamer
n16:MSM0021620816
s:issn
1213-8118
s:numberOfPages
2
n13:organizacniJednotka
11120