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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F06%3A00002136%21RIV11-GA0-11120___
rdf:type
skos:Concept n7:Vysledek
dcterms:description
Alloreactivity is the strongest known primary immune response. Its clinical manifestations are graft rejection, graft-versus-host disease and graft-versus-leukemia effect. The strongest stimulation by allogeneic cells is due to incompatibility at the major histocompatibility complex (MHC) genes. However, the non-MHC genes also participate in allogeneic response. Here we present a mouse model for study of the role of non-MHC genes in regulation of alloreactivity and show that they besides encoding antigens also regulate the responsiveness. Recombinant congenic strains (RCS) of O20/A (O20)-c-B10.O20/Dem (OcB/Dem) series have been derived from the parental strains O20 and B10.O20, which carry identical MHC haplotypes (H-2(pz)) and therefore their differences in alloantigen response depend only on non-MHC genes. We have tested a MLR response by spleen cells of the strains O20, B10.O20, and 16 OcB/Dem strains through stimulation by cells from strains C57BL/10 (H-2(b)), BALB/c (H-2(d)), CBA (H-2(k)), and DB Alloreactivity is the strongest known primary immune response. Its clinical manifestations are graft rejection, graft-versus-host disease and graft-versus-leukemia effect. The strongest stimulation by allogeneic cells is due to incompatibility at the major histocompatibility complex (MHC) genes. However, the non-MHC genes also participate in allogeneic response. Here we present a mouse model for study of the role of non-MHC genes in regulation of alloreactivity and show that they besides encoding antigens also regulate the responsiveness. Recombinant congenic strains (RCS) of O20/A (O20)-c-B10.O20/Dem (OcB/Dem) series have been derived from the parental strains O20 and B10.O20, which carry identical MHC haplotypes (H-2(pz)) and therefore their differences in alloantigen response depend only on non-MHC genes. We have tested a MLR response by spleen cells of the strains O20, B10.O20, and 16 OcB/Dem strains through stimulation by cells from strains C57BL/10 (H-2(b)), BALB/c (H-2(d)), CBA (H-2(k)), and DB
dcterms:title
Mouse model for analysis of non-MHC genes that influence allogeneic response: recombinant congenic strains of OcB/Dem series that carry identical H2 locus Mouse model for analysis of non-MHC genes that influence allogeneic response: recombinant congenic strains of OcB/Dem series that carry identical H2 locus
skos:prefLabel
Mouse model for analysis of non-MHC genes that influence allogeneic response: recombinant congenic strains of OcB/Dem series that carry identical H2 locus Mouse model for analysis of non-MHC genes that influence allogeneic response: recombinant congenic strains of OcB/Dem series that carry identical H2 locus
skos:notation
RIV/00216208:11120/06:00002136!RIV11-GA0-11120___
n5:aktivita
n18:P
n5:aktivity
P(GD310/03/H147)
n5:cisloPeriodika
1
n5:dodaniDat
n17:2011
n5:domaciTvurceVysledku
n8:6111122
n5:druhVysledku
n15:J
n5:duvernostUdaju
n6:S
n5:entitaPredkladatele
n14:predkladatel
n5:idSjednocenehoVysledku
486911
n5:idVysledku
RIV/00216208:11120/06:00002136
n5:jazykVysledku
n13:eng
n5:klicovaSlova
alloresponse; non-MHC genes; mouse genetic model; mixed lymphocyte response; recombinant congenic strains
n5:klicoveSlovo
n11:alloresponse n11:non-MHC%20genes n11:recombinant%20congenic%20strains n11:mixed%20lymphocyte%20response n11:mouse%20genetic%20model
n5:kodStatuVydavatele
PL - Polská republika
n5:kontrolniKodProRIV
[1ABBBAED3064]
n5:nazevZdroje
Central European Journal of Biology
n5:obor
n9:EC
n5:pocetDomacichTvurcuVysledku
1
n5:pocetTvurcuVysledku
4
n5:projekt
n10:GD310%2F03%2FH147
n5:rokUplatneniVysledku
n17:2006
n5:svazekPeriodika
1
n5:tvurceVysledku
Lipoldová, Marie
n5:wos
000246919400003
s:issn
1895-104X
s:numberOfPages
13
n12:organizacniJednotka
11120