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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F06%3A00000669%21RIV09-MSM-11120___
rdf:type
skos:Concept n17:Vysledek
dcterms:description
%22Proteinase-activated%22 receptor-2 (PAR-2) is a G protein-coupled transmembrane receptor with seven transmembrane domains activated by trypsin. It has been shown in the pancreatic tissue that PAR-2 is involved in duct/acinary cells secretion, arterial tonus regulation and capillary liquid content turnover under physiological conditions. These above mentioned structures play an important role during the development of acute pancreatitis and are profoundly influenced by a high concentration of trypsin enzyme after its secretion into the interstitial tissue from the basolateral aspect of acinar cells. Among the other factors, it is the increase of interstitial trypsin concentration followed rapidly by PAR-2 action on pancreatic vascular smooth muscle cells that initiates ischemic changes in pancreatic parenchyma and that finally leads to necrosis of the pancreas. Consequent reperfusion perpetuates changes leading to the acute pancreatitis development. On the contrary, PAR-2 action on both exocrine a %22Proteinase-activated%22 receptor-2 (PAR-2) is a G protein-coupled transmembrane receptor with seven transmembrane domains activated by trypsin. It has been shown in the pancreatic tissue that PAR-2 is involved in duct/acinary cells secretion, arterial tonus regulation and capillary liquid content turnover under physiological conditions. These above mentioned structures play an important role during the development of acute pancreatitis and are profoundly influenced by a high concentration of trypsin enzyme after its secretion into the interstitial tissue from the basolateral aspect of acinar cells. Among the other factors, it is the increase of interstitial trypsin concentration followed rapidly by PAR-2 action on pancreatic vascular smooth muscle cells that initiates ischemic changes in pancreatic parenchyma and that finally leads to necrosis of the pancreas. Consequent reperfusion perpetuates changes leading to the acute pancreatitis development. On the contrary, PAR-2 action on both exocrine a Autoři popisují akutní pankreatitidu a ukazují proteinázou aktivovaný receptor jako Dr. Jekylla a pan Hyda
dcterms:title
Acute pancreatitis: Proteinase-activated receptor-2 as Dr. Jekyll and Mr. Hyde Akutní pankreatitida: proteinázou aktivovaný receptor jako Dr. Jekyll a pan Hyde Acute pancreatitis: Proteinase-activated receptor-2 as Dr. Jekyll and Mr. Hyde
skos:prefLabel
Acute pancreatitis: Proteinase-activated receptor-2 as Dr. Jekyll and Mr. Hyde Akutní pankreatitida: proteinázou aktivovaný receptor jako Dr. Jekyll a pan Hyde Acute pancreatitis: Proteinase-activated receptor-2 as Dr. Jekyll and Mr. Hyde
skos:notation
RIV/00216208:11120/06:00000669!RIV09-MSM-11120___
n3:aktivita
n8:V n8:S
n3:aktivity
S, V
n3:cisloPeriodika
5
n3:dodaniDat
n16:2009
n3:domaciTvurceVysledku
n12:2483327
n3:druhVysledku
n14:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
464106
n3:idVysledku
RIV/00216208:11120/06:00000669
n3:jazykVysledku
n13:eng
n3:klicovaSlova
PAR-2; acute pancreatitis; trypsin
n3:klicoveSlovo
n4:acute%20pancreatitis n4:PAR-2 n4:trypsin
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[770D15BA9C99]
n3:nazevZdroje
Physiological Research
n3:obor
n10:FP
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n16:2006
n3:svazekPeriodika
55
n3:tvurceVysledku
Olejár, T. Matěj, R. Housa, Daniel
n3:wos
000241910900001
s:issn
0862-8408
s:numberOfPages
8
n11:organizacniJednotka
11120