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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F06%3A00000079%21RIV07-MSM-11120___
rdf:type
skos:Concept n19:Vysledek
dcterms:description
NMDA receptory jsou široce rozšířené, ligandy otevírané a napěťově závislé iontové kanály, citlivé současně na L-glutamát a glycin. NMDA receptors are widely distributed, rapidly responding ligand-gated and voltage-dependent cationic channels sensitive to L-glutamate and glycine. The NMDA receptors are essential for the normal function of the excitatory glutamatergic neurotransmission. The receptor/channel complexes are highly permeable to Ca2+ and are subject to regulation by a variety of factors. Usually present as tetramers of protein subunits, NMDA receptors are formed by NR1, NR2 and/or NR3 subunits; however, all functional complexes must include NR1 subunits. The presence of NR2 and NR3 subunits and/or the nature of their spice variants may influence a range of NMDA receptor characteristics such as binding affinities for glutamate and glycine. Altered function of NMDA receptors has been linked to the etilogy of mental disease, particularly as a part of the %22glutmatergic hypothesis of schizophrenia%22. The functional changes in NMDA receptors could result from genetically determined variations in individual protein s NMDA receptory jsou široce rozšířené, ligandy otevírané a napěťově závislé iontové kanály, citlivé současně na L-glutamát a glycin.
dcterms:title
Composition and function of NMDA receptor in schizophrenia: from animal models to a patient Stavba a funkce NMDA receptoru u schizofrenie: od animálních modelů k pacientovi Stavba a funkce NMDA receptoru u schizofrenie: od animálních modelů k pacientovi
skos:prefLabel
Composition and function of NMDA receptor in schizophrenia: from animal models to a patient Stavba a funkce NMDA receptoru u schizofrenie: od animálních modelů k pacientovi Stavba a funkce NMDA receptoru u schizofrenie: od animálních modelů k pacientovi
skos:notation
RIV/00216208:11120/06:00000079!RIV07-MSM-11120___
n3:strany
7-14
n3:aktivita
n4:P n4:Z n4:S
n3:aktivity
P(1M0517), P(NF7626), S, Z(MZ0PCP2005)
n3:cisloPeriodika
Suppl. 2
n3:dodaniDat
n7:2007
n3:domaciTvurceVysledku
n14:6507026 n14:1371576 n14:3462080
n3:druhVysledku
n6:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
501544
n3:idVysledku
RIV/00216208:11120/06:00000079
n3:jazykVysledku
n17:cze
n3:klicovaSlova
glutamate; glycine; D-serine; NMDA receptor; NR1/NR2/NR3 subunits; animal model; schizophrenia
n3:klicoveSlovo
n5:schizophrenia n5:glycine n5:D-serine n5:animal%20model n5:NR1%2FNR2%2FNR3%20subunits n5:glutamate n5:NMDA%20receptor
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[FDC19910FF40]
n3:nazevZdroje
Psychiatrie
n3:obor
n15:FH
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
9
n3:projekt
n10:NF7626 n10:1M0517
n3:rokUplatneniVysledku
n7:2006
n3:svazekPeriodika
10
n3:tvurceVysledku
Balcar, V. J. Peková, S. Mareš, V. Vrajová, Monika Jirásková, J. Kozmiková, I. Šťastný, František Tejkalová, H. Höschl, Cyril
n3:zamer
n18:MZ0PCP2005
s:issn
1211-7579
s:numberOfPages
8
n16:organizacniJednotka
11120