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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F06%3A00000030%21RIV07-MSM-11120___
rdf:type
n12:Vysledek skos:Concept
dcterms:description
OBJECTIVE: Risperidone in antipsychotic doses induces hyperprolactinemia. The aim of this study was to verify whether the same is true for low doses of risperidone (0.5-2 mg per day) added to antidepressants or anxiolytics. METHODS: Prolactin levels were measured in 4 men (mean age 49.5+/-19.1 years) and 8 women (mean age 31.3+/-8.2 years) inpatients with depressive and anxiety disorders who were treated with risperidone (median doses per day 1.25 mg) for median 15.5 days as an augmentation treatment to antidepressants (n=8), anxiolytics (n=6) and mood stabilizers (n=2). RESULTS: 11 of 12 patients had hyperprolactinemia. Median plasma prolactin level was 1598 mIU/ml, 95% CI 1 040-2 661 mIU/ml. Significant correlation between risperidone daily dose and plasma prolactin level (Spearman's R=0.655, p=0.02) was detected. Two women suffered from galactorrhea and one from amenorrhea. CONCLUSIONS: Even low doses of risperidone used as an augmentation to antidepressants or benzodiazepines are associated w OBJECTIVE: Risperidone in antipsychotic doses induces hyperprolactinemia. The aim of this study was to verify whether the same is true for low doses of risperidone (0.5-2 mg per day) added to antidepressants or anxiolytics. METHODS: Prolactin levels were measured in 4 men (mean age 49.5+/-19.1 years) and 8 women (mean age 31.3+/-8.2 years) inpatients with depressive and anxiety disorders who were treated with risperidone (median doses per day 1.25 mg) for median 15.5 days as an augmentation treatment to antidepressants (n=8), anxiolytics (n=6) and mood stabilizers (n=2). RESULTS: 11 of 12 patients had hyperprolactinemia. Median plasma prolactin level was 1598 mIU/ml, 95% CI 1 040-2 661 mIU/ml. Significant correlation between risperidone daily dose and plasma prolactin level (Spearman's R=0.655, p=0.02) was detected. Two women suffered from galactorrhea and one from amenorrhea. CONCLUSIONS: Even low doses of risperidone used as an augmentation to antidepressants or benzodiazepines are associated w Úvod: Risperidon v antipsychotických dávkách vede k hyperprolaktinémii. Cílem této studie bylo objasnit, zdali také nízké dávky risperidonu (0,5-2 mg/denně) přidané k antidepresivům nebo anxiolytikám způsobují hyperprolaktinémii. Metody: Hladina prolaktinu byla měřena u 4 mužů (prům. věk 49,5+/-19,1 let) a 8 žen (prům. věk 31,3+/-8,2 let) hospitalizovaných pro depresivní či úzkostné poruchy. Pacienti byli léčeni risperidonem (medián denní dávky 1,25 mg). Risperidon byl použit jako augmentační léčba antidepresiv (n=8), anxiolytik (n=6) a thymostabilizérů (n=2) po dobu mediánu 15,5 dnů. Výsledky: 11 z 12 pacientů mělo hyperprolaktinémii. Medián plasmatické hladiny prolaktinu byl 1598 mIU/ml, 95% CI 1 040-2 661 mIU/ml. Byla zjištěna signifikatní korelace mezi denní dávkou risperidonu a plasmatickou hladinou prolaktinu (Spearmanovo R=0,655; p=0,02). U dvou žen se objevila galaktorrhea a u jedné amenorrhea. Závěr: I malé dávky risperidonu použité jako augmentace antidepresiv či benzodiazepinů jsou spojené
dcterms:title
Low-dose risperidone augmentation of antidepressants or anxiolytics is associated with hyperprolactinemia Low-dose risperidone augmentation of antidepressants or anxiolytics is associated with hyperprolactinemia Augmentace antidepresiv či anxiolytik nízkými dávkami risperidonu je spojena s hyperprolaktinemií
skos:prefLabel
Low-dose risperidone augmentation of antidepressants or anxiolytics is associated with hyperprolactinemia Augmentace antidepresiv či anxiolytik nízkými dávkami risperidonu je spojena s hyperprolaktinemií Low-dose risperidone augmentation of antidepressants or anxiolytics is associated with hyperprolactinemia
skos:notation
RIV/00216208:11120/06:00000030!RIV07-MSM-11120___
n3:strany
803-806
n3:aktivita
n8:Z
n3:aktivity
Z(MSM0021620816)
n3:cisloPeriodika
6
n3:dodaniDat
n18:2007
n3:domaciTvurceVysledku
n6:5420024 n6:6339824 n6:1965247 n6:2625032
n3:druhVysledku
n17:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
483680
n3:idVysledku
RIV/00216208:11120/06:00000030
n3:jazykVysledku
n15:eng
n3:klicovaSlova
risperidone; prolactinemia; depression; anxiety; side effect; endocrinology
n3:klicoveSlovo
n7:endocrinology n7:anxiety n7:prolactinemia n7:risperidone n7:depression n7:side%20effect
n3:kodStatuVydavatele
SE - Švédské království
n3:kontrolniKodProRIV
[3645705037CE]
n3:nazevZdroje
Neuroendocrinology Letters
n3:obor
n16:FL
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n18:2006
n3:svazekPeriodika
27
n3:tvurceVysledku
Horáček, Jiří Kopeček, Miloslav Bareš, Martin Mohr, Pavel
n3:zamer
n10:MSM0021620816
s:issn
0172-780X
s:numberOfPages
4
n13:organizacniJednotka
11120