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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F06%3A00000024%21RIV07-MSM-11120___
rdf:type
n14:Vysledek skos:Concept
dcterms:description
Objectives: With the aim to indicate the functional anatomical substrate of cognitive dysfunction in schizophrenia we evaluated the relationship between resting brain metabolism and performance on the Trail Making Test (TMT). As the prerequisite analysis we compared the performance in Part A and B of the TMT between schizophrenic patients and controls. Resting brain metabolism was investigated by 18FDG positron emission tomography (PET) as the probe for the relative regional synaptic strength and density. Methods: 18FDG PET data were analyzed by SPM99 with TMT A and B as the covariate (pL0.001). Results: Schizophrenic patients (N=42) had worse performance in both TMT A and B compared to controls (N=42). In schizophrenic subjects 18FDG PET did not predict the performance on Part A (psychomotor speed) but predicted that for Part B (set-shifting and flexibility) of the TMT. The 18FDG uptake in the superior, middle and inferior frontal gyruses bilaterally was associated with better performance in the TMT Objectives: With the aim to indicate the functional anatomical substrate of cognitive dysfunction in schizophrenia we evaluated the relationship between resting brain metabolism and performance on the Trail Making Test (TMT). As the prerequisite analysis we compared the performance in Part A and B of the TMT between schizophrenic patients and controls. Resting brain metabolism was investigated by 18FDG positron emission tomography (PET) as the probe for the relative regional synaptic strength and density. Methods: 18FDG PET data were analyzed by SPM99 with TMT A and B as the covariate (pL0.001). Results: Schizophrenic patients (N=42) had worse performance in both TMT A and B compared to controls (N=42). In schizophrenic subjects 18FDG PET did not predict the performance on Part A (psychomotor speed) but predicted that for Part B (set-shifting and flexibility) of the TMT. The 18FDG uptake in the superior, middle and inferior frontal gyruses bilaterally was associated with better performance in the TMT Východiska: S cílem indikovat funkčně anatomický substrát kognitivní dysfunkce u schizofrenie jsme hodnotili vztah mezi klidovým metabolismem mozku a výkonem při Testu cesty (TMT). Nejprve jsme porovnali výkon v části A a B Testu cesty mezi pacienty trpícícími schizofrenií a kontrolními subjekty. Klidový metabolismus mozku byl vyšetřován 18FDG pozitronovou emisní tomografií (PET) jako indikátor synaptické denzity. Metody: Data z 18FDG PET byla analyzována pomocí SPM99 s částmi A a B Testu cesty jako kovariáty (pL0.001). Výsledky: Pacienti se schizofrenií (N=42) měli horší výkon v obou částech Testu cesty v porovnání s kontrolami (N=42). U subjektů se schizofrenií nepredikovala 18FDG PET výkon v části A Testu cesty (psychomotorická rychlost), ale predikovala ho pro část B Testu cesty (set-shifting a flexibilita). Vychytávání 18FDG v horním, středním a dolním frontálním gyru bilaterálně bylo asociováno s lepším výkonem v části B Testu cesty. Negativní kovariace mezi 18FDG vychytáváním a časem stráveným
dcterms:title
Regional brain metabolism as the predictor of performance on the Trail Making Test in schizophrenia. A 18FDG PET covariation study Regional brain metabolism as the predictor of performance on the Trail Making Test in schizophrenia. A 18FDG PET covariation study Regionální metabolismus mozku jako prediktor výkonu na test cesty u schizofrenie. 18FDG PET kovariační studie
skos:prefLabel
Regionální metabolismus mozku jako prediktor výkonu na test cesty u schizofrenie. 18FDG PET kovariační studie Regional brain metabolism as the predictor of performance on the Trail Making Test in schizophrenia. A 18FDG PET covariation study Regional brain metabolism as the predictor of performance on the Trail Making Test in schizophrenia. A 18FDG PET covariation study
skos:notation
RIV/00216208:11120/06:00000024!RIV07-MSM-11120___
n3:strany
587-594
n3:aktivita
n4:P n4:Z
n3:aktivity
P(1M0517), P(NR8792), Z(MZ0PCP2005)
n3:cisloPeriodika
5
n3:dodaniDat
n12:2007
n3:domaciTvurceVysledku
n7:1371576 n7:3683508 n7:8377146 n7:2625032 n7:7891423 n7:6339824 n7:7303505
n3:druhVysledku
n5:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
496873
n3:idVysledku
RIV/00216208:11120/06:00000024
n3:jazykVysledku
n15:eng
n3:klicovaSlova
Trail Making Test; Positron emission tomography (PET); 18FDG; schizophrenia; cognitive dysfunction
n3:klicoveSlovo
n8:cognitive%20dysfunction n8:18FDG n8:Trail%20Making%20Test n8:Positron%20emission%20tomography%20%28PET%29 n8:schizophrenia
n3:kodStatuVydavatele
SE - Švédské království
n3:kontrolniKodProRIV
[4A779ED17345]
n3:nazevZdroje
Neuroendocrinology Letters
n3:obor
n17:FL
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
9
n3:projekt
n13:1M0517 n13:NR8792
n3:rokUplatneniVysledku
n12:2006
n3:svazekPeriodika
27
n3:tvurceVysledku
Páleníček, Tomáš Novák, T. Tišlerová, Barbora Španiel, Filip Horáček, Jiří Klírová, Monika Dockery, Colleen Kopeček, Miloslav Höschl, Cyril
n3:zamer
n18:MZ0PCP2005
s:issn
0172-780X
s:numberOfPages
13
n16:organizacniJednotka
11120