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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F04%3A00003835%21RIV12-MSM-11120___
rdf:type
n6:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1097/01.rli.0000115332.25954.a3
dcterms:description
Newer radiologic techniques require fast bolus injections and thus low-viscosity, high-concentration, well-tolerated contrast media (CM), especially in vulnerable patients. To this end, we designed and developed iosimenol, a novel isotonic nonionic dimer, and have conducted tests to enable its clinical evaluation. Standard physicochemical methods were used. Effects on erythrocyte morphology and coagulation were investigated in human and rat blood. Neural tolerance was assessed by behavioral tests in rats after intracisternal injection. Immunosensitizing potential was evaluated by the skin sensitization test in guinea pigs and by the popliteal lymph node assay in rats. Pharmacokinetics and biotransformation were investigated in rats and dogs. Iosimenol is extremely hydrophilic, it is less viscous than any other isotonic CM, has little effect on erythrocytes and blood coagulation, and has good neural tolerance. No immunosensitizing effect was found in validated animal models. Pharmacokinetics are identi Newer radiologic techniques require fast bolus injections and thus low-viscosity, high-concentration, well-tolerated contrast media (CM), especially in vulnerable patients. To this end, we designed and developed iosimenol, a novel isotonic nonionic dimer, and have conducted tests to enable its clinical evaluation. Standard physicochemical methods were used. Effects on erythrocyte morphology and coagulation were investigated in human and rat blood. Neural tolerance was assessed by behavioral tests in rats after intracisternal injection. Immunosensitizing potential was evaluated by the skin sensitization test in guinea pigs and by the popliteal lymph node assay in rats. Pharmacokinetics and biotransformation were investigated in rats and dogs. Iosimenol is extremely hydrophilic, it is less viscous than any other isotonic CM, has little effect on erythrocytes and blood coagulation, and has good neural tolerance. No immunosensitizing effect was found in validated animal models. Pharmacokinetics are identi
dcterms:title
Iosimenol, a low-viscosity nonionic dimer - Preclinical physicochemistry, pharmacology, and pharmacokinetics Iosimenol, a low-viscosity nonionic dimer - Preclinical physicochemistry, pharmacology, and pharmacokinetics
skos:prefLabel
Iosimenol, a low-viscosity nonionic dimer - Preclinical physicochemistry, pharmacology, and pharmacokinetics Iosimenol, a low-viscosity nonionic dimer - Preclinical physicochemistry, pharmacology, and pharmacokinetics
skos:notation
RIV/00216208:11120/04:00003835!RIV12-MSM-11120___
n3:aktivita
n14:N
n3:aktivity
N
n3:cisloPeriodika
3
n3:dodaniDat
n11:2012
n3:domaciTvurceVysledku
n18:7286600
n3:druhVysledku
n10:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
568982
n3:idVysledku
RIV/00216208:11120/04:00003835
n3:jazykVysledku
n5:eng
n3:klicovaSlova
iosimenol; nonionic dimer; pharmacokinetics; viscosity; toxicology; x-ray contrast media
n3:klicoveSlovo
n8:nonionic%20dimer n8:viscosity n8:iosimenol n8:pharmacokinetics n8:x-ray%20contrast%20media n8:toxicology
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[CCB791EBFA50]
n3:nazevZdroje
Investigative Radiology
n3:obor
n4:FK
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
11
n3:rokUplatneniVysledku
n11:2004
n3:svazekPeriodika
39
n3:tvurceVysledku
Sovak, M. Fišerová, Magdaléna
n3:wos
000189320200006
s:issn
0020-9996
s:numberOfPages
11
n13:doi
10.1097/01.rli.0000115332.25954.a3
n19:organizacniJednotka
11120