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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F04%3A00001133%21RIV%2F2005%2FMZ0%2F111205%2FN
rdf:type
n11:Vysledek skos:Concept
dcterms:description
Experimental model based on the C5 ventral root avulsion was used to evaluate the efficacy of brain-derived neurotrophic factor (BDNF) and Cerebrolysin treatment on motor neuron maintenance and survival resulted in the functional reinnervation of the nerve stump. In contrast to vehicle, BDNF treatment reduced the loss and atrophy of motor neurons and enhanced the regrowth axon sprouts into the distal stump of musculocutaneous nerve. However, the axon diameter of the myelinated fibers was smaller than those of control rats. The morphometric results were related to a low score in behavioral test similar to vehicle-treated rats. Cerebrolysin treatment greatly protected the motor neurons against cell death. Moreover, morphometric features of myelinated axons were better than those of rats treated with vehicle or BDNF. The mean score of grooming test suggested better results of the functional motor reinnervation than after BDNF administration. Experimental model based on the C5 ventral root avulsion was used to evaluate the efficacy of brain-derived neurotrophic factor (BDNF) and Cerebrolysin treatment on motor neuron maintenance and survival resulted in the functional reinnervation of the nerve stump. In contrast to vehicle, BDNF treatment reduced the loss and atrophy of motor neurons and enhanced the regrowth axon sprouts into the distal stump of musculocutaneous nerve. However, the axon diameter of the myelinated fibers was smaller than those of control rats. The morphometric results were related to a low score in behavioral test similar to vehicle-treated rats. Cerebrolysin treatment greatly protected the motor neurons against cell death. Moreover, morphometric features of myelinated axons were better than those of rats treated with vehicle or BDNF. The mean score of grooming test suggested better results of the functional motor reinnervation than after BDNF administration. Práce popisuje reinervaci pahýlu krysího nervus musculocutaneus po jeho přímém znovuspojení na míšní segment C5 nervovým štěpem následkem avulze ventrální míšních kořenů: srovnání intratekálního podání mozkově derivovaného neurotrofického faktoru a Cerebrosylinu
dcterms:title
Reinnervation of the rat musculocutaneous nerve stump after its direct reconnection with the C5 spinal cord segment by the nerve graft following avulsion of the ventral spinal roots Reinervace pahýlu krysího nervus musculocutaneus po jeho přímém znovuspojení na míšní segment C5 nervovým štěpem následkem avulze ventrální míšních kořenů Reinnervation of the rat musculocutaneous nerve stump after its direct reconnection with the C5 spinal cord segment by the nerve graft following avulsion of the ventral spinal roots
skos:prefLabel
Reinervace pahýlu krysího nervus musculocutaneus po jeho přímém znovuspojení na míšní segment C5 nervovým štěpem následkem avulze ventrální míšních kořenů Reinnervation of the rat musculocutaneous nerve stump after its direct reconnection with the C5 spinal cord segment by the nerve graft following avulsion of the ventral spinal roots Reinnervation of the rat musculocutaneous nerve stump after its direct reconnection with the C5 spinal cord segment by the nerve graft following avulsion of the ventral spinal roots
skos:notation
RIV/00216208:11120/04:00001133!RIV/2005/MZ0/111205/N
n3:strany
425;432
n3:aktivita
n18:P
n3:aktivity
P(NF6658)
n3:cisloPeriodika
4
n3:dodaniDat
n12:2005
n3:domaciTvurceVysledku
n10:2930021 n10:4973445 n10:8536864
n3:druhVysledku
n16:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
584121
n3:idVysledku
RIV/00216208:11120/04:00001133
n3:jazykVysledku
n8:eng
n3:klicovaSlova
Reinnervation;musculocutaneous;nerve;stump;after;direct;reconnection;spinal;segment;nerve;graft;following;avulsion;ventral;spinal;roots;comparison;intrathecal;administration;brain-derived;neurotrophic
n3:klicoveSlovo
n4:roots n4:ventral n4:administration n4:reconnection n4:segment n4:comparison n4:Reinnervation n4:following n4:musculocutaneous n4:after n4:spinal n4:brain-derived n4:stump n4:intrathecal n4:avulsion n4:graft n4:neurotrophic n4:nerve n4:direct
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[231E7E8ABC1F]
n3:nazevZdroje
Experimental Brain Research
n3:obor
n9:FH
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
5
n3:projekt
n17:NF6658
n3:rokUplatneniVysledku
n12:2004
n3:svazekPeriodika
159
n3:tvurceVysledku
Haninec, Pavel Šámal, Filip Houšťava, Ladislav
s:issn
0014-4819
s:numberOfPages
8
n5:organizacniJednotka
11120