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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F03%3A00003831%21RIV12-MSM-11120___
rdf:type
skos:Concept n9:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1128/Iai.71.4.2041-2046.2003
dcterms:description
The mouse strains BALB/cHeA (BALB/c) and STS/A (STS) are susceptible and resistant to Leishmania major-induced disease, respectively. We analyzed this difference using recombinant congenic (RC) BALB/c-c-STS/Dem (CcS/Dem) strains that carry different random subsets of 12.5% genes of the strain STS in a BALB/c background. Previously, testing the resistant strain CcS-5, we found five novel Lmr (Leishmania major response) loci, each associated with a different combination of pathological and immunological reactions. Here we analyze the response of RC strain CcS-16, which is even more susceptible to L. major than BALB/c. In the (CcS-16 x BALB/c)F-2 hybrids we mapped three novel loci that influence cutaneous or visceral pathology. Lmr14 (chromosome 2) controls splenomegaly and hepatomegaly. On the other hand Lmr15 (chromosome 11) determines hepatomegaly only, and Lmr13 (chromosome 18) determines skin lesions only. These data confirm the complex control of L. major-induced pathology, where cutaneous and visc The mouse strains BALB/cHeA (BALB/c) and STS/A (STS) are susceptible and resistant to Leishmania major-induced disease, respectively. We analyzed this difference using recombinant congenic (RC) BALB/c-c-STS/Dem (CcS/Dem) strains that carry different random subsets of 12.5% genes of the strain STS in a BALB/c background. Previously, testing the resistant strain CcS-5, we found five novel Lmr (Leishmania major response) loci, each associated with a different combination of pathological and immunological reactions. Here we analyze the response of RC strain CcS-16, which is even more susceptible to L. major than BALB/c. In the (CcS-16 x BALB/c)F-2 hybrids we mapped three novel loci that influence cutaneous or visceral pathology. Lmr14 (chromosome 2) controls splenomegaly and hepatomegaly. On the other hand Lmr15 (chromosome 11) determines hepatomegaly only, and Lmr13 (chromosome 18) determines skin lesions only. These data confirm the complex control of L. major-induced pathology, where cutaneous and visc
dcterms:title
Different genetic control of cutaneous and visceral disease after Leishmania major infection in mice Different genetic control of cutaneous and visceral disease after Leishmania major infection in mice
skos:prefLabel
Different genetic control of cutaneous and visceral disease after Leishmania major infection in mice Different genetic control of cutaneous and visceral disease after Leishmania major infection in mice
skos:notation
RIV/00216208:11120/03:00003831!RIV12-MSM-11120___
n3:aktivita
n12:S n12:P n12:Z
n3:aktivity
P(GA310/00/0760), P(GA310/03/1381), P(OK 394), S, Z(AV0Z5052915), Z(MSM 113100004)
n3:cisloPeriodika
4
n3:dodaniDat
n19:2012
n3:domaciTvurceVysledku
n14:8506051 n14:6111122
n3:druhVysledku
n15:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
603840
n3:idVysledku
RIV/00216208:11120/03:00003831
n3:jazykVysledku
n10:eng
n3:klicovaSlova
recombinant congenic strains; multiple loci; nitric-oxide; susceptibility; linkage; heterogeneity; resistance; immunity; 5Q31-Q33; traits
n3:klicoveSlovo
n4:immunity n4:recombinant%20congenic%20strains n4:multiple%20loci n4:nitric-oxide n4:heterogeneity n4:5Q31-Q33 n4:traits n4:resistance n4:susceptibility n4:linkage
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[0040475956F1]
n3:nazevZdroje
Infection and Immunity
n3:obor
n16:EC
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
8
n3:projekt
n8:GA310%2F00%2F0760 n8:GA310%2F03%2F1381 n8:OK%20394
n3:rokUplatneniVysledku
n19:2003
n3:svazekPeriodika
71
n3:tvurceVysledku
Badalová, Jana Lipoldová, Marie
n3:wos
000181926200053
n3:zamer
n13:MSM%20113100004 n13:AV0Z5052915
s:issn
0019-9567
s:numberOfPages
6
n5:doi
10.1128/Iai.71.4.2041-2046.2003
n20:organizacniJednotka
11120