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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F03%3A00002204%21RIV11-MZ0-11120___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
It is unresolved whether elevated homocysteine in coronary artery disease (CAD) is the cause of arteriosclerosis or its consequence. In contrast, genetic variants of enzymes that metabolize homocysteine cannot be altered by arteriosclerosis. Consequently, their association with CAD would permit to imply causality. We modeled by regression analysis the effect of 11 variants in the methionine cycle upon CAD manifestation in 591 controls and 278 CAD patients. Among the examined variants only the carriership, for the c.844ins68 in the cystathionine beta-synthase (CBS) gene was associated with a significantly lowered risk of CAD (OR = 0.56; 95% CI = 0.35-0.90 in the univariable, and OR = 0.41, 95% CI = 0.19-0.89 for obese people in the multivariable analysis, respectively). Healthy carriers of the c.844ins68 variant exhibited, compared to the wild type controls, significantly higher postload ratios of blood S-adenosylmethionine to S-adenosylhomocysteine (61.4 vs. 54.9, p = 0.001) and of plasma total cystei It is unresolved whether elevated homocysteine in coronary artery disease (CAD) is the cause of arteriosclerosis or its consequence. In contrast, genetic variants of enzymes that metabolize homocysteine cannot be altered by arteriosclerosis. Consequently, their association with CAD would permit to imply causality. We modeled by regression analysis the effect of 11 variants in the methionine cycle upon CAD manifestation in 591 controls and 278 CAD patients. Among the examined variants only the carriership, for the c.844ins68 in the cystathionine beta-synthase (CBS) gene was associated with a significantly lowered risk of CAD (OR = 0.56; 95% CI = 0.35-0.90 in the univariable, and OR = 0.41, 95% CI = 0.19-0.89 for obese people in the multivariable analysis, respectively). Healthy carriers of the c.844ins68 variant exhibited, compared to the wild type controls, significantly higher postload ratios of blood S-adenosylmethionine to S-adenosylhomocysteine (61.4 vs. 54.9, p = 0.001) and of plasma total cystei
dcterms:title
Genetic variants of homocysteine metabolizing enzymes and the risk of coronary artery disease Genetic variants of homocysteine metabolizing enzymes and the risk of coronary artery disease
skos:prefLabel
Genetic variants of homocysteine metabolizing enzymes and the risk of coronary artery disease Genetic variants of homocysteine metabolizing enzymes and the risk of coronary artery disease
skos:notation
RIV/00216208:11120/03:00002204!RIV11-MZ0-11120___
n3:aktivita
n7:P n7:Z
n3:aktivity
P(NM26), P(NM6548), Z(MSM 111100003)
n3:cisloPeriodika
3
n3:dodaniDat
n18:2011
n3:domaciTvurceVysledku
n14:8831955 n14:7278772 n14:7496915
n3:druhVysledku
n19:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
608156
n3:idVysledku
RIV/00216208:11120/03:00002204
n3:jazykVysledku
n17:eng
n3:klicovaSlova
coronary disease; risk factors; genes; homocysteine; metabolism
n3:klicoveSlovo
n6:metabolism n6:risk%20factors n6:genes n6:homocysteine n6:coronary%20disease
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[85F31848ABC3]
n3:nazevZdroje
Molecular Genetics and Metabolism
n3:obor
n13:EB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
13
n3:projekt
n12:NM6548 n12:NM26
n3:rokUplatneniVysledku
n18:2003
n3:svazekPeriodika
79
n3:tvurceVysledku
Anděl, Michal Vítová, Andrea Janošíková, B. Kraml, Pavel
n3:wos
000184304300003
n3:zamer
n8:MSM%20111100003
s:issn
1096-7192
s:numberOfPages
9
n9:organizacniJednotka
11120