This HTML5 document contains 39 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n6http://localhost/temp/predkladatel/
n11http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n8http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n16http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00216208%3A11120%2F02%3A00003696%21RIV12-MSM-11120___/
n5http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n9http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n14http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n7http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n15http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n10http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F02%3A00003696%21RIV12-MSM-11120___
rdf:type
n8:Vysledek skos:Concept
dcterms:description
Cisplatin is widely used as an antitumor drug. To reduce its toxic side effects in patients, cisplatin has been bound with procaine in a cisplatin-procaine complex (DPR). The lethal and teratogenic effects of cisplatin alone and of complexcd cisplatin were determined in the chick embryo in ovo in order to compare their influence on rapidly proliferating embryonic tissues. The embryotoxic (lethal + teratogenic) effect was examined after a single intra-amniotic injection of one of six different doses, ranging from 0.03 to30.0 mug, on embryonic days (ED) 3, 4 or 5. The minimal embryotoxic dose was lower for cisplatin alone (0.03-0.3 mug) than for cisplatin in the DPR complex (0.3-3.0 mug), suggesting that cisplatin alone is more embryotoxic than complexed cisplatin. Both substances caused malformations in the surviving embryos evaluated on ED 9. These malformations included microphthalmia, Microcephaly, hypoplasia of the upper and lower jaw, cleft beak, and haemocephaly. Moreover. heart septum defects an Cisplatin is widely used as an antitumor drug. To reduce its toxic side effects in patients, cisplatin has been bound with procaine in a cisplatin-procaine complex (DPR). The lethal and teratogenic effects of cisplatin alone and of complexcd cisplatin were determined in the chick embryo in ovo in order to compare their influence on rapidly proliferating embryonic tissues. The embryotoxic (lethal + teratogenic) effect was examined after a single intra-amniotic injection of one of six different doses, ranging from 0.03 to30.0 mug, on embryonic days (ED) 3, 4 or 5. The minimal embryotoxic dose was lower for cisplatin alone (0.03-0.3 mug) than for cisplatin in the DPR complex (0.3-3.0 mug), suggesting that cisplatin alone is more embryotoxic than complexed cisplatin. Both substances caused malformations in the surviving embryos evaluated on ED 9. These malformations included microphthalmia, Microcephaly, hypoplasia of the upper and lower jaw, cleft beak, and haemocephaly. Moreover. heart septum defects an
dcterms:title
Embryotoxicity of cisplatin nad a cisplatin-procaine complex (DPR) studied in chick embryo Embryotoxicity of cisplatin nad a cisplatin-procaine complex (DPR) studied in chick embryo
skos:prefLabel
Embryotoxicity of cisplatin nad a cisplatin-procaine complex (DPR) studied in chick embryo Embryotoxicity of cisplatin nad a cisplatin-procaine complex (DPR) studied in chick embryo
skos:notation
RIV/00216208:11120/02:00003696!RIV12-MSM-11120___
n3:aktivita
n7:V
n3:aktivity
V
n3:cisloPeriodika
6
n3:dodaniDat
n10:2012
n3:domaciTvurceVysledku
n11:7449186
n3:druhVysledku
n17:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
644930
n3:idVysledku
RIV/00216208:11120/02:00003696
n3:jazykVysledku
n14:eng
n3:klicovaSlova
cisplatin; cisplatin procaine complex DPR; teratogen; malformation
n3:klicoveSlovo
n5:teratogen n5:cisplatin n5:malformation n5:cisplatin%20procaine%20complex%20DPR
n3:kodStatuVydavatele
SK - Slovenská republika
n3:kontrolniKodProRIV
[EC862746FA7B]
n3:nazevZdroje
Neoplasma
n3:obor
n15:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n10:2002
n3:svazekPeriodika
49
n3:tvurceVysledku
Peterka, Miroslav Mandys, Václav
n3:wos
000180614700007
s:issn
0028-2685
s:numberOfPages
7
n6:organizacniJednotka
11120