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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F02%3A00003695%21RIV12-MSM-11120___
rdf:type
skos:Concept n14:Vysledek
dcterms:description
More than a decade of experimental work in an inbred subline of Sprague-Dawley rats having high incidence of spontaneous T-cell lymphoma/leukaemia is reviewed. Longitudinal follow-up of biological characteristics (growth, survival, haematology) of both multiple cases of primary disease and s.c. passaged lymphomas as well as comparative immunophenotypic and karyotypic studies are concluded. In these T-cell lymphomas (mostly CD4 positive), arising on the same genetic background of the inbred SD strain, the aberrations involving chromosome 11 have been recognized as a typical non-random cytogenetic marker. This unique rat model of lymphoblastic lymphomas/leukaemias, relevant to human pathology, seems to be very suitable for testing different anticancer therapeutic strategies, as it is documented by results of a number of various protocols conducted in our laboratory. More than a decade of experimental work in an inbred subline of Sprague-Dawley rats having high incidence of spontaneous T-cell lymphoma/leukaemia is reviewed. Longitudinal follow-up of biological characteristics (growth, survival, haematology) of both multiple cases of primary disease and s.c. passaged lymphomas as well as comparative immunophenotypic and karyotypic studies are concluded. In these T-cell lymphomas (mostly CD4 positive), arising on the same genetic background of the inbred SD strain, the aberrations involving chromosome 11 have been recognized as a typical non-random cytogenetic marker. This unique rat model of lymphoblastic lymphomas/leukaemias, relevant to human pathology, seems to be very suitable for testing different anticancer therapeutic strategies, as it is documented by results of a number of various protocols conducted in our laboratory.
dcterms:title
Relevant animal model of human lymphoblastic leukaemia/lymphoma - Spontaneous T-cell lymphomas in an inbred sprague-dawley rat strain (SD/Cub) Relevant animal model of human lymphoblastic leukaemia/lymphoma - Spontaneous T-cell lymphomas in an inbred sprague-dawley rat strain (SD/Cub)
skos:prefLabel
Relevant animal model of human lymphoblastic leukaemia/lymphoma - Spontaneous T-cell lymphomas in an inbred sprague-dawley rat strain (SD/Cub) Relevant animal model of human lymphoblastic leukaemia/lymphoma - Spontaneous T-cell lymphomas in an inbred sprague-dawley rat strain (SD/Cub)
skos:notation
RIV/00216208:11120/02:00003695!RIV12-MSM-11120___
n6:aktivita
n15:V n15:Z
n6:aktivity
V, Z(AV0Z5039906), Z(MSM 111100004)
n6:cisloPeriodika
6
n6:dodaniDat
n10:2012
n6:domaciTvurceVysledku
n12:7449186
n6:druhVysledku
n18:J
n6:duvernostUdaju
n16:S
n6:entitaPredkladatele
n17:predkladatel
n6:idSjednocenehoVysledku
662042
n6:idVysledku
RIV/00216208:11120/02:00003695
n6:jazykVysledku
n9:eng
n6:klicovaSlova
T-cell; lymphoma; leukaemia; rat model; immunophenotype; cytogenetics; cell cycle; immunochemistry; experimental therapy
n6:klicoveSlovo
n7:immunophenotype n7:cytogenetics n7:rat%20model n7:immunochemistry n7:T-cell n7:experimental%20therapy n7:leukaemia n7:lymphoma n7:cell%20cycle
n6:kodStatuVydavatele
CZ - Česká republika
n6:kontrolniKodProRIV
[B75583D6E966]
n6:nazevZdroje
Folia Biologica
n6:obor
n8:FD
n6:pocetDomacichTvurcuVysledku
1
n6:pocetTvurcuVysledku
6
n6:rokUplatneniVysledku
n10:2002
n6:svazekPeriodika
48
n6:tvurceVysledku
Otová, B. Mandys, Václav
n6:wos
000180060500001
n6:zamer
n11:MSM%20111100004 n11:AV0Z5039906
s:issn
0015-5500
s:numberOfPages
13
n13:organizacniJednotka
11120