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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F02%3A00002993%21RIV12-GA0-11120___
rdf:type
skos:Concept n19:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1016/s0165-5728(02)00211-4
dcterms:description
The involvement of catecholamine receptors (alpha-adrenergic, D2-dopamine (DA)) was investigated in restraint stress influenced immune responses with concomitant changes of G-protein signal transduction. Impairment of the spleen morphology, TH1/TH2 cytokine network and natural killer (NK) cell function was observed. In vivo administration of specific antagonists prior to restraint stress reversed the immunosuppression. These findings demonstrate that D2-type dopaminergic mechanism represents the dominant component in regulation of Galphas/Galphai(1,2)/Galphaq/11-protein signal transduction and contribute to cell responses at postreceptor level of both, central nervous and immune systems. G-protein-coupled receptors (GPCRs) can modulate cytokine production and may play a regulatory role in immune effector mechanisms The involvement of catecholamine receptors (alpha-adrenergic, D2-dopamine (DA)) was investigated in restraint stress influenced immune responses with concomitant changes of G-protein signal transduction. Impairment of the spleen morphology, TH1/TH2 cytokine network and natural killer (NK) cell function was observed. In vivo administration of specific antagonists prior to restraint stress reversed the immunosuppression. These findings demonstrate that D2-type dopaminergic mechanism represents the dominant component in regulation of Galphas/Galphai(1,2)/Galphaq/11-protein signal transduction and contribute to cell responses at postreceptor level of both, central nervous and immune systems. G-protein-coupled receptors (GPCRs) can modulate cytokine production and may play a regulatory role in immune effector mechanisms
dcterms:title
Effect of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune responsiveness of mice Effect of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune responsiveness of mice
skos:prefLabel
Effect of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune responsiveness of mice Effect of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune responsiveness of mice
skos:notation
RIV/00216208:11120/02:00002993!RIV12-GA0-11120___
n5:aktivita
n15:P
n5:aktivity
P(GA310/98/0347)
n5:cisloPeriodika
1-2
n5:dodaniDat
n8:2012
n5:domaciTvurceVysledku
n9:7018398
n5:druhVysledku
n16:J
n5:duvernostUdaju
n18:S
n5:entitaPredkladatele
n11:predkladatel
n5:idSjednocenehoVysledku
644175
n5:idVysledku
RIV/00216208:11120/02:00002993
n5:jazykVysledku
n10:eng
n5:klicovaSlova
restraint stress; cytokine; NK cell
n5:klicoveSlovo
n6:cytokine n6:NK%20cell n6:restraint%20stress
n5:kodStatuVydavatele
NL - Nizozemsko
n5:kontrolniKodProRIV
[D69ED90D69B0]
n5:nazevZdroje
Journal of Neuroimmunology
n5:obor
n7:ED
n5:pocetDomacichTvurcuVysledku
1
n5:pocetTvurcuVysledku
7
n5:projekt
n20:GA310%2F98%2F0347
n5:rokUplatneniVysledku
n8:2002
n5:svazekPeriodika
130
n5:tvurceVysledku
Starec, Miroslav Fišerová, Anna
n5:wos
000178329200006
s:issn
0165-5728
s:numberOfPages
11
n12:doi
10.1016/s0165-5728(02)00211-4
n17:organizacniJednotka
11120