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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F01%3A00003664%21RIV12-MSM-11120___
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Antitumour efficiency of combined therapy with N-9[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP) and docetaxel (DTX) was studied in an in vivo model of s.c. transplanted Sprague-Dawley (SD/Cub) rat T-cell lymphoma (phenotype SD10/96). The effect of the combined treatment of DTX with PMEDAP was significantly higher than that of DTX or PMEDAP alone. The s.c. administration of DXT into the vicinity of growing lymphoma together with i.p. administration of PMEDAP was found to be the most efficient combination. In this case, two out of four rats did not develop any lymphoma and remained alive. An irregular expression of Bcl2 protein was found in untreated and treated lymphomas, while the expression of protein p53 as well as MDM2 was not observed. All three types of the above-mentioned treatments (PMEDAP, DXT, DXT+PMEDAP) increased significantly the number of p21-positive cells, compared with untreated tumours. Antitumour efficiency of combined therapy with N-9[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP) and docetaxel (DTX) was studied in an in vivo model of s.c. transplanted Sprague-Dawley (SD/Cub) rat T-cell lymphoma (phenotype SD10/96). The effect of the combined treatment of DTX with PMEDAP was significantly higher than that of DTX or PMEDAP alone. The s.c. administration of DXT into the vicinity of growing lymphoma together with i.p. administration of PMEDAP was found to be the most efficient combination. In this case, two out of four rats did not develop any lymphoma and remained alive. An irregular expression of Bcl2 protein was found in untreated and treated lymphomas, while the expression of protein p53 as well as MDM2 was not observed. All three types of the above-mentioned treatments (PMEDAP, DXT, DXT+PMEDAP) increased significantly the number of p21-positive cells, compared with untreated tumours.
dcterms:title
Antitumour activity of a combined treatment with PMEDAP and docetaxel in the Prague inbred Sprague-Dawley/cub rat strain bearing T-cell lymphoma Antitumour activity of a combined treatment with PMEDAP and docetaxel in the Prague inbred Sprague-Dawley/cub rat strain bearing T-cell lymphoma
skos:prefLabel
Antitumour activity of a combined treatment with PMEDAP and docetaxel in the Prague inbred Sprague-Dawley/cub rat strain bearing T-cell lymphoma Antitumour activity of a combined treatment with PMEDAP and docetaxel in the Prague inbred Sprague-Dawley/cub rat strain bearing T-cell lymphoma
skos:notation
RIV/00216208:11120/01:00003664!RIV12-MSM-11120___
n3:aktivita
n13:P n13:Z
n3:aktivity
P(GV203/96/K001), P(NL5423), Z(AV0Z4055905), Z(MSM 111200001)
n3:cisloPeriodika
4A
n3:dodaniDat
n11:2012
n3:domaciTvurceVysledku
n4:7449186
n3:druhVysledku
n14:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
673534
n3:idVysledku
RIV/00216208:11120/01:00003664
n3:jazykVysledku
n7:eng
n3:klicovaSlova
rat; spontaneous lymphoma; PMEDAP; docetaxel
n3:klicoveSlovo
n9:docetaxel n9:PMEDAP n9:rat n9:spontaneous%20lymphoma
n3:kodStatuVydavatele
GR - Řecká republika
n3:kontrolniKodProRIV
[F623621D3D9A]
n3:nazevZdroje
Anticancer Research
n3:obor
n19:EA
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:projekt
n5:GV203%2F96%2FK001 n5:NL5423
n3:rokUplatneniVysledku
n11:2001
n3:svazekPeriodika
21
n3:tvurceVysledku
Mandys, Václav Bobkov, K.
n3:wos
000171984700069
n3:zamer
n15:MSM%20111200001 n15:AV0Z4055905
s:issn
0250-7005
s:numberOfPages
7
n17:organizacniJednotka
11120