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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F01%3A00003661%21RIV12-MSM-11120___
rdf:type
n15:Vysledek skos:Concept
dcterms:description
PSA is the most important of all tumor markers because it has significant applications in all aspects of the management of men with prostatic disease. Certainly, the most important utilization of PSA is for early detection of this most ubiquitous of all human neoplasms. In this article the authors describe the molecular forms of PSA and their characteristics, the factors influencing values of serum concentration of PSA, the problems of screening, and particularly the possibility to use PSA for detection of prostate carcinoma. A big problem in prostate carcinoma detection is the low specificity of PSA at the concentrations between 4-10 ng/ml, the so-called diagnostic gray zone, where the incidence of prostate carcinoma is only 25%, The authors evaluate the methods which make it possible to increase the sensitivity and/or specificity of PSA detection, such as PSA density, PSA density of the transition zone, PSA velocity, PSA doubling time, age-specific PSA, free PSA and, prospectively, the use of the RT PSA is the most important of all tumor markers because it has significant applications in all aspects of the management of men with prostatic disease. Certainly, the most important utilization of PSA is for early detection of this most ubiquitous of all human neoplasms. In this article the authors describe the molecular forms of PSA and their characteristics, the factors influencing values of serum concentration of PSA, the problems of screening, and particularly the possibility to use PSA for detection of prostate carcinoma. A big problem in prostate carcinoma detection is the low specificity of PSA at the concentrations between 4-10 ng/ml, the so-called diagnostic gray zone, where the incidence of prostate carcinoma is only 25%, The authors evaluate the methods which make it possible to increase the sensitivity and/or specificity of PSA detection, such as PSA density, PSA density of the transition zone, PSA velocity, PSA doubling time, age-specific PSA, free PSA and, prospectively, the use of the RT
dcterms:title
Prostate-specific antigen: Current status Prostate-specific antigen: Current status
skos:prefLabel
Prostate-specific antigen: Current status Prostate-specific antigen: Current status
skos:notation
RIV/00216208:11120/01:00003661!RIV12-MSM-11120___
n4:aktivita
n17:Z
n4:aktivity
Z(MSM 111200002)
n4:cisloPeriodika
2
n4:dodaniDat
n6:2012
n4:domaciTvurceVysledku
n9:6858074 n9:7476396 n9:1708007 n9:9709126 n9:8778981 n9:7692641
n4:druhVysledku
n12:J
n4:duvernostUdaju
n16:S
n4:entitaPredkladatele
n14:predkladatel
n4:idSjednocenehoVysledku
693453
n4:idVysledku
RIV/00216208:11120/01:00003661
n4:jazykVysledku
n11:eng
n4:klicovaSlova
prostate-specific antigen; tumor markers; prostate cancer; benign prostatic hyperplasia
n4:klicoveSlovo
n7:prostate%20cancer n7:tumor%20markers n7:benign%20prostatic%20hyperplasia n7:prostate-specific%20antigen
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[2CEA0A9779E1]
n4:nazevZdroje
Folia Biologica
n4:obor
n18:FP
n4:pocetDomacichTvurcuVysledku
6
n4:pocetTvurcuVysledku
6
n4:rokUplatneniVysledku
n6:2001
n4:svazekPeriodika
47
n4:tvurceVysledku
Žďárský, Emanuel Záleský, Miroslav Lukeš, Martin Heráček, Jiří Zachoval, Roman Urban, Michael
n4:wos
000167820700001
n4:zamer
n5:MSM%20111200002
s:issn
0015-5500
s:numberOfPages
9
n3:organizacniJednotka
11120