This HTML5 document contains 44 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n12http://localhost/temp/predkladatel/
n20http://linked.opendata.cz/resource/domain/vavai/projekt/
n10http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n17http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
rdfshttp://www.w3.org/2000/01/rdf-schema#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n18http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00216208%3A11120%2F01%3A00003616%21RIV12-MZ0-11120___/
n7http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n6http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n15http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n9http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n5http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n19http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n11http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n13http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F01%3A00003616%21RIV12-MZ0-11120___
rdf:type
skos:Concept n17:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1007/BF03035134
dcterms:description
There is an increasing evidence that corticosteroids damage the hippocampus in rodents and in primates. Hippocampal atrophy induced by corticosteroids may play an important role in the pathogenesis of a range of neuropsychiatric disorders. Hippocampus is necessary for short-term memory consolidation and HPA axis regulation. Signs of hippocampal damage (HPA dysregulation in combination with memory impairment) are found in affective disorders, Alzheimer's disease and in posttraumatic stress disorder. MRI volumetry reveals reduced hippocampal volume in these diseases. Evidence supporting the %22glucocorticoid hypothesis%22 of psychiatric disorders is reviewed in the first part of the paper. Unresolved questions concerning temporary aspects of neurodegeneration, causality, reversibility, type of damage, factors increasing hippocampal vulnerability, and both pharmacological (CRH antagonists, antiglucocorticoid drugs, GABA-ergic, serotonergic, glutamatergic agents) and non-pharmacological There is an increasing evidence that corticosteroids damage the hippocampus in rodents and in primates. Hippocampal atrophy induced by corticosteroids may play an important role in the pathogenesis of a range of neuropsychiatric disorders. Hippocampus is necessary for short-term memory consolidation and HPA axis regulation. Signs of hippocampal damage (HPA dysregulation in combination with memory impairment) are found in affective disorders, Alzheimer's disease and in posttraumatic stress disorder. MRI volumetry reveals reduced hippocampal volume in these diseases. Evidence supporting the %22glucocorticoid hypothesis%22 of psychiatric disorders is reviewed in the first part of the paper. Unresolved questions concerning temporary aspects of neurodegeneration, causality, reversibility, type of damage, factors increasing hippocampal vulnerability, and both pharmacological (CRH antagonists, antiglucocorticoid drugs, GABA-ergic, serotonergic, glutamatergic agents) and non-pharmacological
dcterms:title
Hippocampal Damage Mediated by Corticosteroids a Neuropsychiatric Research Challenge Hippocampal Damage Mediated by Corticosteroids a Neuropsychiatric Research Challenge
skos:prefLabel
Hippocampal Damage Mediated by Corticosteroids a Neuropsychiatric Research Challenge Hippocampal Damage Mediated by Corticosteroids a Neuropsychiatric Research Challenge
skos:notation
RIV/00216208:11120/01:00003616!RIV12-MZ0-11120___
n3:aktivita
n9:P
n3:aktivity
P(NF6489)
n3:cisloPeriodika
Suppl. 2
n3:dodaniDat
n13:2012
n3:domaciTvurceVysledku
n10:2224151 n10:1371576
n3:druhVysledku
n11:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
681655
n3:idVysledku
RIV/00216208:11120/01:00003616
n3:jazykVysledku
n5:eng
n3:klicovaSlova
Hippocampus; corticosteroids; affective disorders; posttraumatic stress disorder; Alzheimer's disease
n3:klicoveSlovo
n6:posttraumatic%20stress%20disorder n6:corticosteroids n6:affective%20disorders n6:Alzheimer%27s%20disease n6:Hippocampus
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[370F0B50B448]
n3:nazevZdroje
European Archives of Psychiatry and Clinical Neuroscience
n3:obor
n19:FL
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:projekt
n20:NF6489
n3:rokUplatneniVysledku
n13:2001
n3:svazekPeriodika
251
n3:tvurceVysledku
Höschl, Cyril Hájek, Tomáš
n3:wos
000207579000017
s:issn
0940-1334
s:numberOfPages
8
n7:doi
10.1007/BF03035134
n12:organizacniJednotka
11120