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Statements

Subject Item
n2:RIV%2F00216208%3A11120%2F01%3A00003604%21RIV12-GA0-11120___
rdf:type
skos:Concept n19:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1002/1521-3900(200107)172:1<157::aid-masy157>3.0.co;2-k
dcterms:description
In our attempt to prepare new hydrogels for cell encapsulation, we decided to use synthetic copolymers presuming that chemical bonds should bring better mechanical stability of capsules than electrostatic forces between polyanions and polycations in the so far predominantly used materials based on polyelectrolyte complexes. Two series of copolymers of 2-hydroxyethyl methacrylate (HEMA) with alkyl acrylates (methacrylates) or N-alkylacrylamides (methacrylamides) were prepared. The copolymers, prepared by Solution copolymerization in ethanol, were characterized by swelling in water and PBS solution, viscometric molecular weight, and NMR analysis, and their encapsulation processability was tested. Their characteristics and the first biological tests are the subject of this paper. In our attempt to prepare new hydrogels for cell encapsulation, we decided to use synthetic copolymers presuming that chemical bonds should bring better mechanical stability of capsules than electrostatic forces between polyanions and polycations in the so far predominantly used materials based on polyelectrolyte complexes. Two series of copolymers of 2-hydroxyethyl methacrylate (HEMA) with alkyl acrylates (methacrylates) or N-alkylacrylamides (methacrylamides) were prepared. The copolymers, prepared by Solution copolymerization in ethanol, were characterized by swelling in water and PBS solution, viscometric molecular weight, and NMR analysis, and their encapsulation processability was tested. Their characteristics and the first biological tests are the subject of this paper.
dcterms:title
Hydrogels for encapsulation of mammalian cells Hydrogels for encapsulation of mammalian cells
skos:prefLabel
Hydrogels for encapsulation of mammalian cells Hydrogels for encapsulation of mammalian cells
skos:notation
RIV/00216208:11120/01:00003604!RIV12-GA0-11120___
n4:aktivita
n13:P n13:Z
n4:aktivity
P(GA304/98/0267), P(KSK2055603), Z(AV0Z4050913)
n4:cisloPeriodika
1
n4:dodaniDat
n17:2012
n4:domaciTvurceVysledku
n11:7922795
n4:druhVysledku
n9:J
n4:duvernostUdaju
n18:S
n4:entitaPredkladatele
n14:predkladatel
n4:idSjednocenehoVysledku
682126
n4:idVysledku
RIV/00216208:11120/01:00003604
n4:jazykVysledku
n7:eng
n4:klicovaSlova
Microencapsulation; Biocompatibility; Copolymers; Culture; Transplantation; Microcapsules; Permeability; Hepatocytes
n4:klicoveSlovo
n8:Permeability n8:Microencapsulation n8:Transplantation n8:Microcapsules n8:Biocompatibility n8:Hepatocytes n8:Copolymers n8:Culture
n4:kodStatuVydavatele
DE - Spolková republika Německo
n4:kontrolniKodProRIV
[A8A6592229A5]
n4:nazevZdroje
Macromolecular Symposia
n4:obor
n6:CD
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
5
n4:projekt
n15:GA304%2F98%2F0267 n15:KSK2055603
n4:rokUplatneniVysledku
n17:2001
n4:svazekPeriodika
172
n4:tvurceVysledku
Dvořánková, Barbora Lukáš, Jaromír
n4:wos
000170297900018
n4:zamer
n5:AV0Z4050913
s:issn
1022-1360
s:numberOfPages
9
n20:doi
10.1002/1521-3900(200107)172:1<157::aid-masy157>3.0.co;2-k
n10:organizacniJednotka
11120