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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F14%3A10291098%21RIV15-MSM-11110___
rdf:type
skos:Concept n19:Vysledek
rdfs:seeAlso
http://www.clinsci.org/cs/126/0593/1260593.pdf
dcterms:description
Innate immune cells, particularly macrophages and epithelial cells, play a key role in multiple layers of immune responses. Alarmins and pro-inflammatory cytokines from the IL (interleukin)-1 and TNF (tumour necrosis factor) families initiate the cascade of events by inducing chemokine release from bystander cells and by the up-regulation of adhesion molecules required for transendothelial trafficking of immune cells. Furthermore, innate cytokines produced by dendritic cells, macrophages, epithelial cells and innate lymphoid cells seem to play a critical role in polarization of helper T-cell cytokine profiles into specific subsets of Th1/Th2/Th17 effector cells or regulatory T-cells. Lastly, the innate immune system down-regulates effector mechanisms and restores homoeostasis in injured tissue via cytokines from the IL-10 and TGF (transforming growth factor) families mainly released from macrophages, preferentially the M2 subset, which have a capacity to induce regulatory T-cells, inhibit the production of pro-inflammatory cytokines and induce healing of the tissue by regulating extracellular matrix protein deposition and angiogenesis. Cytokines produced by innate immune cells represent an attractive target for therapeutic intervention, and multiple molecules are currently being tested clinically in patients with inflammatory bowel disease, rheumatoid arthritis, systemic diseases, autoinflammatory syndromes, fibrosing processes or malignancies. In addition to the already widely used blockers of TNF alpha and the tested inhibitors of IL-1 and IL-6, multiple therapeutic molecules are currently in clinical trials targeting TNF-related molecules [APRIL (a proliferation-inducing ligand) and BAFF (B-cell-activating factor belonging to the TNF family)], chemokine receptors, IL-17, TGF beta and other cytokines. Innate immune cells, particularly macrophages and epithelial cells, play a key role in multiple layers of immune responses. Alarmins and pro-inflammatory cytokines from the IL (interleukin)-1 and TNF (tumour necrosis factor) families initiate the cascade of events by inducing chemokine release from bystander cells and by the up-regulation of adhesion molecules required for transendothelial trafficking of immune cells. Furthermore, innate cytokines produced by dendritic cells, macrophages, epithelial cells and innate lymphoid cells seem to play a critical role in polarization of helper T-cell cytokine profiles into specific subsets of Th1/Th2/Th17 effector cells or regulatory T-cells. Lastly, the innate immune system down-regulates effector mechanisms and restores homoeostasis in injured tissue via cytokines from the IL-10 and TGF (transforming growth factor) families mainly released from macrophages, preferentially the M2 subset, which have a capacity to induce regulatory T-cells, inhibit the production of pro-inflammatory cytokines and induce healing of the tissue by regulating extracellular matrix protein deposition and angiogenesis. Cytokines produced by innate immune cells represent an attractive target for therapeutic intervention, and multiple molecules are currently being tested clinically in patients with inflammatory bowel disease, rheumatoid arthritis, systemic diseases, autoinflammatory syndromes, fibrosing processes or malignancies. In addition to the already widely used blockers of TNF alpha and the tested inhibitors of IL-1 and IL-6, multiple therapeutic molecules are currently in clinical trials targeting TNF-related molecules [APRIL (a proliferation-inducing ligand) and BAFF (B-cell-activating factor belonging to the TNF family)], chemokine receptors, IL-17, TGF beta and other cytokines.
dcterms:title
Cytokine networking of innate immunity cells: a potential target of therapy Cytokine networking of innate immunity cells: a potential target of therapy
skos:prefLabel
Cytokine networking of innate immunity cells: a potential target of therapy Cytokine networking of innate immunity cells: a potential target of therapy
skos:notation
RIV/00216208:11110/14:10291098!RIV15-MSM-11110___
n3:aktivita
n6:V
n3:aktivity
V
n3:cisloPeriodika
9-10
n3:dodaniDat
n12:2015
n3:domaciTvurceVysledku
n15:7194641
n3:druhVysledku
n17:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
9547
n3:idVysledku
RIV/00216208:11110/14:10291098
n3:jazykVysledku
n18:eng
n3:klicovaSlova
biologics; mucosal immunity; Immunomodulation; cytokine
n3:klicoveSlovo
n14:cytokine n14:Immunomodulation n14:biologics n14:mucosal%20immunity
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[3F01176F6F35]
n3:nazevZdroje
Clinical Science
n3:obor
n4:EC
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n12:2014
n3:svazekPeriodika
126
n3:tvurceVysledku
Kolesar, Libor Stříž, Ilja Sekerkova, Alena Brabcova, Eva
n3:wos
000335284000001
s:issn
0143-5221
s:numberOfPages
20
n13:doi
10.1042/CS20130497
n16:organizacniJednotka
11110