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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F14%3A10290555%21RIV15-MSM-11110___
rdf:type
n20:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1007/s00193-013-0462-7
dcterms:description
The generator of two focused successive (tandem) shock waves (FTSW) in water produced by underwater multichannel electrical discharges at two composite electrodes, with a time delay between the first and second shock waves of 10 mu s, was developed. It produces, at the focus, a strong shock wave with a peak positive pressure of up to 80 MPa, followed by a tensile wave with a peak negative pressure of up to -80 MPa, thus generating at the focus a large amount of cavitation. Biological effects of FTSW were demonstrated in vitro on hemolysis of erythrocytes and cell viability of human acute lymphoblastic leukemia cells as well as on tumor growth delay ex vivo and in vivo experiments performed with B16 melanoma, T-lymphoma, and R5-28 sarcoma cell lines. It was demonstrated in vivo that FTSW can enhance antitumor effects of chemotherapeutic drugs, such as cisplatin, most likely due to increased permeability of the membrane of cancer cells induced by FTSW. Synergetic cytotoxicity of FTSW with sonosensitive porphyrin-based drug Photosan on tumor growth was observed, possibly due to the cavitation-induced sonodynamic effect of FTSW. The generator of two focused successive (tandem) shock waves (FTSW) in water produced by underwater multichannel electrical discharges at two composite electrodes, with a time delay between the first and second shock waves of 10 mu s, was developed. It produces, at the focus, a strong shock wave with a peak positive pressure of up to 80 MPa, followed by a tensile wave with a peak negative pressure of up to -80 MPa, thus generating at the focus a large amount of cavitation. Biological effects of FTSW were demonstrated in vitro on hemolysis of erythrocytes and cell viability of human acute lymphoblastic leukemia cells as well as on tumor growth delay ex vivo and in vivo experiments performed with B16 melanoma, T-lymphoma, and R5-28 sarcoma cell lines. It was demonstrated in vivo that FTSW can enhance antitumor effects of chemotherapeutic drugs, such as cisplatin, most likely due to increased permeability of the membrane of cancer cells induced by FTSW. Synergetic cytotoxicity of FTSW with sonosensitive porphyrin-based drug Photosan on tumor growth was observed, possibly due to the cavitation-induced sonodynamic effect of FTSW.
dcterms:title
Focused tandem shock waves in water and their potential application in cancer treatment Focused tandem shock waves in water and their potential application in cancer treatment
skos:prefLabel
Focused tandem shock waves in water and their potential application in cancer treatment Focused tandem shock waves in water and their potential application in cancer treatment
skos:notation
RIV/00216208:11110/14:10290555!RIV15-MSM-11110___
n3:aktivita
n14:I n14:P n14:Z
n3:aktivity
I, P(GA202/09/1151), Z(MSM0021620808)
n3:cisloPeriodika
1
n3:dodaniDat
n21:2015
n3:domaciTvurceVysledku
n5:3233960 n5:9018670 n5:7604696 n5:5205255 n5:7846983
n3:druhVysledku
n11:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
17139
n3:idVysledku
RIV/00216208:11110/14:10290555
n3:jazykVysledku
n12:eng
n3:klicovaSlova
Biomedical application; Multichannel underwater discharge; Focused tandem shock waves
n3:klicoveSlovo
n7:Multichannel%20underwater%20discharge n7:Focused%20tandem%20shock%20waves n7:Biomedical%20application
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[7949FECDB490]
n3:nazevZdroje
Shock Waves
n3:obor
n13:FD
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
12
n3:projekt
n19:GA202%2F09%2F1151
n3:rokUplatneniVysledku
n21:2014
n3:svazekPeriodika
24
n3:tvurceVysledku
Lukes, P. Hoffer, P. Binder, S. Beneš, Jiří Zadinová, Marie Kolarova, H. Sunka, P. Poučková, Pavla Zeman, Jan Tomankova, K. Dibdiak, Lukáš Stelmashuk, V.
n3:wos
000331656400007
n3:zamer
n4:MSM0021620808
s:issn
0938-1287
s:numberOfPages
7
n17:doi
10.1007/s00193-013-0462-7
n16:organizacniJednotka
11110