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Statements

Subject Item
n2:RIV%2F00216208%3A11110%2F14%3A10289861%21RIV15-MSM-11110___
rdf:type
n7:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1016/j.neuroscience.2013.12.010
dcterms:description
Age-related hearing loss (presbycusis) is caused mainly by the hypofunction of the inner ear, but recent findings point also toward a central component of presbycusis. We used MR morphometry and diffusion tensor imaging (DTI) with a 3 T MR system with the aim to study the state of the central auditory system in a group of elderly subjects (> 65 years) with mild presbycusis, in a group of elderly subjects with expressed presbycusis and in young controls. Cortical reconstruction, volumetric segmentation and auditory pathway tractography were performed. Three parameters were evaluated by morphometry: the volume of the gray matter, the surface area of the gyrus and the thickness of the cortex. In all experimental groups the surface area and gray matter volume were larger on the left side in Heschl's gyrus and planum temporale and slightly larger in the gyrus frontalis superior, whereas they were larger on the right side in the primary visual cortex. Almost all of the measured parameters were significantly smaller in the elderly subjects in Heschl's gyrus, planum temporale and gyrus frontalis superior. Aging did not change the side asymmetry (laterality) of the gyri. In the central part of the auditory pathway above the inferior colliculus, a trend toward an effect of aging was present in the axial vector of the diffusion (L1) variable of DTI, with increased values observed in elderly subjects. A trend toward a decrease of L1 on the left side, which was more pronounced in the elderly groups, was observed. The effect of hearing loss was present in subjects with expressed presbycusis as a trend toward an increase of the radial vectors (L2L3) in the white matter under Heschl's gyrus. These results suggest that in addition to peripheral changes, changes in the central part of the auditory system in elderly subjects are also present; however, the extent of hearing loss does not play a significant role in the central changes. Age-related hearing loss (presbycusis) is caused mainly by the hypofunction of the inner ear, but recent findings point also toward a central component of presbycusis. We used MR morphometry and diffusion tensor imaging (DTI) with a 3 T MR system with the aim to study the state of the central auditory system in a group of elderly subjects (> 65 years) with mild presbycusis, in a group of elderly subjects with expressed presbycusis and in young controls. Cortical reconstruction, volumetric segmentation and auditory pathway tractography were performed. Three parameters were evaluated by morphometry: the volume of the gray matter, the surface area of the gyrus and the thickness of the cortex. In all experimental groups the surface area and gray matter volume were larger on the left side in Heschl's gyrus and planum temporale and slightly larger in the gyrus frontalis superior, whereas they were larger on the right side in the primary visual cortex. Almost all of the measured parameters were significantly smaller in the elderly subjects in Heschl's gyrus, planum temporale and gyrus frontalis superior. Aging did not change the side asymmetry (laterality) of the gyri. In the central part of the auditory pathway above the inferior colliculus, a trend toward an effect of aging was present in the axial vector of the diffusion (L1) variable of DTI, with increased values observed in elderly subjects. A trend toward a decrease of L1 on the left side, which was more pronounced in the elderly groups, was observed. The effect of hearing loss was present in subjects with expressed presbycusis as a trend toward an increase of the radial vectors (L2L3) in the white matter under Heschl's gyrus. These results suggest that in addition to peripheral changes, changes in the central part of the auditory system in elderly subjects are also present; however, the extent of hearing loss does not play a significant role in the central changes.
dcterms:title
Diffusion tensor imaging and MR morphometry of the central auditory pathway and auditory cortex in aging Diffusion tensor imaging and MR morphometry of the central auditory pathway and auditory cortex in aging
skos:prefLabel
Diffusion tensor imaging and MR morphometry of the central auditory pathway and auditory cortex in aging Diffusion tensor imaging and MR morphometry of the central auditory pathway and auditory cortex in aging
skos:notation
RIV/00216208:11110/14:10289861!RIV15-MSM-11110___
n4:aktivita
n8:P n8:I
n4:aktivity
I, P(GA13-23940S), P(GAP304/10/1872), P(GBP304/12/G069)
n4:cisloPeriodika
February
n4:dodaniDat
n5:2015
n4:domaciTvurceVysledku
n19:6172245
n4:druhVysledku
n12:J
n4:duvernostUdaju
n20:S
n4:entitaPredkladatele
n13:predkladatel
n4:idSjednocenehoVysledku
11516
n4:idVysledku
RIV/00216208:11110/14:10289861
n4:jazykVysledku
n11:eng
n4:klicovaSlova
diffusion tensor imaging; MR morphometry; auditory pathway; auditory cortex; aging; presbycusis
n4:klicoveSlovo
n6:aging n6:auditory%20pathway n6:presbycusis n6:auditory%20cortex n6:diffusion%20tensor%20imaging n6:MR%20morphometry
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[7FDD04B1EBF2]
n4:nazevZdroje
Neuroscience
n4:obor
n15:FH
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
6
n4:projekt
n17:GBP304%2F12%2FG069 n17:GA13-23940S n17:GAP304%2F10%2F1872
n4:rokUplatneniVysledku
n5:2014
n4:svazekPeriodika
260
n4:tvurceVysledku
Skoch, A. Balogová, Zuzana Hlinka, J. Syka, J. Profant, Oliver Tintera, J.
n4:wos
000330598100008
s:issn
0306-4522
s:numberOfPages
11
n3:doi
10.1016/j.neuroscience.2013.12.010
n18:organizacniJednotka
11110